- ►endojournals.org JL Evans, ID Goldfine, BA Maddux, GM … - Endocrine Reviews, 2002 - Endocrine Soc In both type 1 and type 2 diabetes, the late diabetic complications in nerve,
vascular endothelium, and kidney arise from chronic elevations of glucose and
possibly other metabolites including free fatty acids (FFA). Recent ... Cited by 593 - Related articles - BL Direct - All 18 versions
- ►diabetesjournals.org GC Weir, S Bonner-Weir - Diabetes, 2004 - Am Diabetes Assoc This article proposes five stages in the progression of diabetes, each of which
is characterized by different changes in ß-cell mass, phenotype, and function.
Stage 1 is compensation: insulin secretion increases to maintain ... Cited by 161 - Related articles - BL Direct - All 5 versions
K Maedler, J Oberholzer, P Bucher, GA … - Diabetes, 2003 - Am Diabetes Assoc Glucotoxicity and lipotoxicity contribute to the impaired β-cell function
observed in type 2 diabetes. Here we examine the effect of saturated and
monounsaturated fatty acids at different glucose concentrations on human ... Cited by 149 - Related articles - BL Direct - All 5 versions
MY Donath, J Størling, K Maedler, T Mandrup … - Journal of Molecular Medicine, 2003 - Springer Abstract Pancreatic islet β-cell death occurs in type 1 and 2 diabetes
mellitus, leading to absolute or relative insulin deficiency. β-cell death in
type 1 diabetes is due predominantly to autoimmunity. In type 2 diabetes ... Cited by 145 - Related articles - BL Direct - All 3 versions
H Kaneto, G Xu, N Fujii, S Kim, S Bonner- … - Journal of Biological Chemistry, 2002 - ASBMB Oxidative stress, which is found in pancreatic β-cells in the diabetic state,
suppresses insulin gene transcription and secretion, but the signaling pathways
involved in the β-cell dysfunction induced by oxidative stress remain ... Cited by 132 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org [PDF] GA Gutman, KG Chandy, S Grissmer, M … - Pharmacological reviews, 2005 - ASPET GEORGE A. GUTMAN, K. GEORGE CHANDY, STEPHAN GRISSMER, MICHEL LAZDUNSKI, DAVID
MCKINNON, LUIS A. PARDO, GAIL A. ROBERTSON, BERNARDO RUDY, MICHAEL C.
SANGUINETTI, WALTER STU¨ HMER, AND XIAOLIANG WANG Department of ... Cited by 128 - Related articles - BL Direct - All 9 versions
MY Donath, PA Halban - Diabetologia, 2004 - Springer Increasing evidence indicates that decreased functional beta-cell mass is the
hallmark of both Type 1 and Type 2 diabetes. This underlies the absolute or
relative insu- lin insufficiency in both conditions. In this For Debate, we ... Cited by 123 - Related articles - BL Direct - All 6 versions
- ►jbc.org DR Laybutt, A Sharma, DC Sgroi, J Gaudet, S … - Journal of Biological Chemistry, 2002 - ASBMB In models of type 2 diabetes the expression of -cell genes is altered, but these
changes have not fully explained the impairment in -cell function. We
hypothesized that changes in -cell phenotype and global alterations in both ... Cited by 97 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org R Bottino, AN Balamurugan, H Tse, C … - Diabetes, 2004 - Am Diabetes Assoc The process of human islet isolation triggers a cascade of stressful events in
the islets of Langerhans involving activation of apoptosis and necrosis and the
production of proinflammatory molecules that negatively influence islet ... Cited by 72 - Related articles - BL Direct - All 4 versions
