- ►karolinskauniversitetssjukhuset.se [PDF] SR Salpeter, E Greyber, GA Pasternak, EE … - Archives of Internal …, 2003 - archinte.highwire.org Methods A comprehensive search was performed to identify all comparative trials or observational
cohort studies published between January 1, 1959, and March 31, 2002, that evaluated metformin
therapy, alone or in combination with other treatments, for at least 1 month. The incidence ... Cited by 322 - Related articles - BL Direct - All 16 versions
- ►endojournals.org H Bays, L Mandarino, RA DeFronzo - Journal of Clinical Endocrinology & …, 2004 - Endocrine Soc Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance in liver and muscle and
impaired insulin secretion. Considerable evidence also implicates deranged adipocyte metabolism
and altered fat topography in the pathogenesis of glucose intolerance in T2DM. 1) Fat ... Cited by 245 - Related articles - All 4 versions
WA Hsueh, CJ Lyon, MJ Quiñones - The American journal of medicine, 2004 - Elsevier There is increasing evidence of a parallel progression between insulin resistance and endothelial
dysfunction, suggesting a close association between insulin action and the endothelium. Numerous
studies have demonstrated that endothelial dysfunction occurs early in the ... Cited by 151 - Related articles - All 9 versions
- ►endojournals.org I Pavo, G Jermendy, TT Varkonyi, Z Kerenyi, A … - Journal of Clinical …, 2003 - Endocrine Soc Pioglitazone, a thiazolidinedione, improves glycemic control primarily by increasing peripheral
insulin sensitivity in patients with type 2 diabetes, whereas metformin, a biguanide, exerts its
effect primarily by decreasing hepatic glucose output. In the first head-to-head, ... Cited by 104 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org K Hällsten, KA Virtanen, F Lönnqvist, H Sipilä, A … - Diabetes, 2002 - Am Diabetes Assoc Rosiglitazone, a thiazolidinedione, enhances peripheral insulin sensitivity in patients with type
2 diabetes. Because the synergic action of insulin and exercise has been shown to be decreased
in insulin resistance, the aim of this study was to compare the effects of rosiglitazone and ... Cited by 98 - Related articles - BL Direct - All 6 versions
M Beeson, MP Sajan, M Dizon, D Grebenev, J Gomez- … - Diabetes, 2003 - Am Diabetes Assoc Insulin resistance in type 2 diabetes is partly due to impaired glucose transport in skeletal
muscle. Atypical protein kinase C (aPKC) and protein kinase B (PKB), operating downstream
of phosphatidylinositol (PI) 3-kinase and its lipid product, PI-3,4,5-(PO 4 ) 3 (PIP 3 ), ... Cited by 90 - Related articles - BL Direct - All 4 versions
GD Tan, BA Fielding, JM Currie, SM Humphreys, M … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: We investigated the effects of rosiglitazone on NEFA and triglyceride
metabolism in type 2 diabetes. Methods: In a double-blind, placebo-con- trolled, cross-over study
of rosiglitazone in diet-treated type 2 diabetic subjects, we measured arteriovenous dif- ... Cited by 85 - Related articles - All 2 versions
Y Miyazaki, H He, LJ Mandarino, RA DeFronzo - Diabetes, 2003 - Am Diabetes Assoc Thiazolidinediones (TZDs) improve glycemic control and insulin sensitivity in patients with type
2 diabetes. To determine whether the TZD-induced improvement in glycemic control is associated
with enhanced insulin receptor signaling in skeletal muscle, 20 type 2 diabetic patients ... Cited by 74 - Related articles - BL Direct - All 8 versions
N Musi, LJ Goodyear - Acta Physiologica Scandinavica, 2003 - interscience.wiley.com The AMP-activated protein kinase (AMPK) is an enzyme that is activated in situations where
there are changes in the cellular energy status such as muscle contraction and hypoxia. AMPK
can also be pharmacologically activated by the compound 5-aminoimidazole-4- ... Cited by 62 - Related articles - BL Direct - All 4 versions
RA DeFronzo - International Journal of Clinical Practice, 2004 - interscience.wiley.com Type 2 diabetes is characterized by insulin resistance and impaired insulin secretion. Considerable
evidence implicates altered fat topography and defects in adipocyte metabolism in the pathogenesis
of type 2 diabetes. In individuals who develop type 2 diabetes, fat cells tend to be ... Cited by 54 - Related articles - BL Direct - All 4 versions
