- ►fafp.org [PDF] RA DeFronzo - Medical Clinics of North America, 2004 - Elsevier A discussion of the pathogenesis of type 2 diabetes mellitus must start with a
review of mechanisms involved in the maintenance of normal glucose homeostasis
in the basal or postabsorptive state (10–12 h overnight fast) and ... Cited by 692 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org R Belfort, L Mandarino, S Kashyap, K Wirfel, … - Diabetes, 2005 - Am Diabetes Assoc The dose-response relationship between elevated plasma free fatty acid (FFA)
levels and impaired insulin-mediated glucose disposal and insulin signaling was
examined in 21 lean, healthy, normal glucose-tolerant subjects. Following a ... Cited by 86 - Related articles - All 5 versions
K Højlund, P Stæhr, BF Hansen, KA Green, … - Diabetes, 2003 - Am Diabetes Assoc In type 2 diabetes, insulin activation of muscle glycogen synthase (GS) is
impaired. This defect plays a major role for the development of insulin
resistance and hyperglycemia. In animal muscle, insulin activates GS by ... Cited by 58 - Related articles - BL Direct - All 4 versions
CY Christ-Roberts, T Pratipanawatr, W … - Metabolism, 2004 - Elsevier Exercise training improves insulin sensitivity in subjects with and without type
2 diabetes. However, the mechanism by which this occurs is unclear. The present
study was undertaken to determine how improved insulin signaling, GLUT4 ... Cited by 53 - Related articles - All 13 versions
- ►endojournals.org C Bouche, S Serdy, CR Kahn, AB Goldfine - Endocrine reviews, 2004 - Endocrine Soc Type 2 diabetes is a complex disorder with diminished insulin secretion and
insulin action contributing to the hyperglycemia and wide range of metabolic
defects that underlie the disease. The contribution of glucose metabolic ... Cited by 51 - Related articles - BL Direct - All 6 versions
- ►physiology.org CY Christ-Roberts, T Pratipanawatr, W … - Journal of Applied Physiology, 2003 - Am Physiological Soc The purpose of this study was to determine the factors contributing to the
ability of exercise to enhance insulin-stimulated glucose disposal. Sixteen
insulin-resistant nondiabetic and seven Type 2 diabetic subjects underwent ... Cited by 25 - Related articles - BL Direct - All 5 versions
J Rosenstock, K Wyne - Textbook of Type 2 Diabetes - books.google.com 11 Insulin treatment in type 2 diabetes Julio Rosenstock and Kathleen Wyne
INTRODUCTION Type 2 diabetes mellitus is clearly a progressive disease, with a
relentless decline in insulin secre- tion1. The therapeutic armamentarium ... Cited by 18 - Related articles
HC Gerstein, J Rosenstock - Endocrinology and metabolism clinics of North America, 2005 - Elsevier There is growing recognition that the rapid rise in the prevalence of diabetes
mellitus and lesser degrees of dysglycemia, in concert with the high levels of
associated risk factors for cardiovascular (CV) disease, presages a global ... Cited by 14 - Related articles - All 3 versions
J Rosenstock, MC Riddle - Cefalu, WT, Gerich JE, LeRoithD, eds. The CADRE …, 2004 - cadre-diabetes.com ACHIEVING AND SUSTAINING NORMOGLYCEMIA WITH INSULIN THERAPY As discussed
elsewhere in this book, the target glycemic level is as near to normal as
possible, as measured using hemoglobin A1C (A1C). Normal A1C is 4% to 6%. ... Cited by 14 - Related articles - View as HTML - All 6 versions
K Hojlund, H Beck-Nielsen - Current Diabetes Reviews, 2006 - ingentaconnect.com Abstract: Insulin resistance in skeletal muscle is a major hallmark of type 2
diabetes and an early detectable abnormality in the development of this disease.
The cellular mechanisms of insulin resistance include impaired ... Cited by 7 - Related articles - BL Direct - All 2 versions
