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Scholar Results 1 - 10 of about 36 citing Howlett: Insulin signaling after exercise in insulin receptor substrate-2-deficient mice. (0.09 sec) 

Physical activity/exercise and type 2 diabetes

- biosino.org [PDF]  - Free from Publisher
RJ Sigal, GP Kenny, DH Wasserman, C … - Diabetes care, 2004 - Am Diabetes Assoc
For decades, exercise has been considered a cornerstone of diabetes management,
along with diet and medication. However, high-quality evidence on the importance
of exercise and fitness in diabetes was lacking until recent years. The ...
Cited by 374 - Related articles - BL Direct - All 16 versions

Exercise effects on muscle insulin signaling and action: Invited Review: Intracellular …

- physiology.org
K Sakamoto, LJ Goodyear - Journal of Applied Physiology, 2002 - Am Physiological Soc
Physical exercise is a significant stimulus for the regulation of multiple
metabolic and transcriptional processes in skeletal muscle. For example,
exercise increases skeletal muscle glucose uptake, and, after exercise, ...
Cited by 151 - Related articles - BL Direct - All 3 versions

Skeletal muscle glucose uptake during exercise: how is it regulated?

- physiology.org
AJ Rose, EA Richter - Physiology, 2005 - Am Physiological Soc
During dynamic exercise, the turnover of ATP in skeletal muscle increases
greatly and is fuelled by the catabolism of carbohydrates (intramuscular
glycogen, blood glucose) and fatty acids (intramuscular triglycerides, ...
Cited by 60 - Related articles - BL Direct - All 4 versions

Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on …

- jbc.org
J Giraud, R Leshan, YH Lee, MF White - Journal of Biological Chemistry, 2004 - ASBMB
Ser/Thr phosphorylation of insulin receptor substrate IRS-1 regulates insulin
signaling, but the relevant phosphorylated residues and their potential
functions during insulin-stimulated signal transduction are difficult to ...
Cited by 58 - Related articles - BL Direct - All 6 versions

Exercise Effects on Muscle Insulin Signaling and Action: Invited Review: Effect of acute …

- physiology.org
JFP Wojtaszewski, JN Nielsen, EA Richter - Journal of Applied Physiology, 2002 - Am Physiological Soc
After a single bout of exercise, insulin action is increased in the muscles that
were active during exercise. The increased insulin action has been shown to
involve glucose transport, glycogen synthesis, and glycogen synthase (GS) ...
Cited by 53 - Related articles - BL Direct - All 3 versions

Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth

- nih.gov
X Dong, S Park, X Lin, K Copps, X Yi, MF … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig
Insulin receptor substrates, including Irs1 and Irs2, integrate insulin and IGF
receptor signals with heterologous pathways to coordinate growth and metabolism.
Since Irs2 is thought to be especially important in hepatic nutrient ...
Cited by 36 - Related articles - BL Direct - All 12 versions

Insulin signalling: effects of prior exercise


JFP Wojtaszewski, SB Jorgensen, C Frosig, C … - Acta Physiologica Scandinavica, 2003 - interscience.wiley.com
After the discovery and clinical use of insulin for treatment of diabetes it
became clear that some of the biological effect of insulin was dependent on the
circumstances under which it was given. Relevant for this review is the ...
Cited by 34 - Related articles - BL Direct - All 4 versions

Exercise training-induced improvements in insulin action


JA Hawley, SJ Lessard - Acta Physiologica, 2008 - interscience.wiley.com
Individuals with insulin resistance are characterized by impaired insulin action
on whole-body glucose uptake, in part due to impaired insulin-stimulated glucose
uptake into skeletal muscle. A single bout of exercise increases skeletal ...
Cited by 35 - Related articles - BL Direct - All 3 versions

Insulin-stimulated insulin receptor substrate-2–associated phosphatidylinositol 3–kinase …


KF Howlett, K Sakamoto, H Yu, LJ Goodyear, … - Metabolism, 2006 - Elsevier
Exercise increases skeletal muscle insulin action but the underlying mechanisms
mediating this are equivocal. In mouse skeletal muscle, prior exercise enhances
insulin-stimulated insulin receptor substrate-2 (IRS-2) signaling (Diabetes ...
Cited by 26 - Related articles - All 12 versions

Glucose ingestion during exercise blunts exercise-induced gene expression of skeletal …

- physiology.org
AE Civitarese, MKC Hesselink, AP Russell, E … - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc
Ingestion of carbohydrate during exercise may blunt the stimulation of fat
oxidative pathways by raising plasma insulin and glucose concentrations and
lowering plasma free fatty acid (FFA) levels, thereby causing a marked ...
Cited by 17 - Related articles - BL Direct - All 4 versions


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