- ►diabetesjournals.org AI Vinik, RE Maser, BD Mitchell, R Freeman - Diabetes care, 2003 - Am Diabetes Assoc Diabetic autonomic neuropathy (DAN) is a serious and common complication of diabetes. Despite
its relationship to an increased risk of cardiovascular mortality and its association with multiple
symptoms and impairments, the significance of DAN has not been fully appreciated. The ... Cited by 490 - Related articles - BL Direct - All 14 versions
- ►nih.gov X Du, T Matsumura, D Edelstein, L Rossetti … - Journal of Clinical …, 2003 - Am Soc Clin Investig In this report, we show that hyperglycemia-induced overproduction of superoxide by the mitochondrial
electron transport chain activates the three major pathways of hyperglycemic damage found
in aortic endothelial cells by inhibiting GAPDH activity. In bovine aortic endothelial cells, ... Cited by 292 - Related articles - BL Direct - All 11 versions
- ►diabetesjournals.org A Ceriello - Diabetes care, 2003 - Am Diabetes Assoc Evidence implicates hyperglycemia-derived oxygen free radicals as mediators of diabetic
complications. However, intervention studies with classic antioxidants, such as vitamin E, failed
to demonstrate any beneficial effect. Recent studies demonstrate that a single ... Cited by 284 - Related articles - All 9 versions
S Boudina, ED Abel - Circulation, 2007 - Am Heart Assoc The prevalence of diabetes mellitus is growing rapidly. It is estimated that globally the number
of adults affected with diabetes will increase from 135 million in 1995 to 300 million by 2025.
1 Patients with diabetes mellitus are at increased risk for cardiovascular diseases. Thus, ... Cited by 140 - Related articles - All 5 versions
- ►inotekcorp.com [PDF] GJ Southan, C Szab - Current medicinal chemistry, 2003 - ingentaconnect.com Abstract: Poly(ADP-ribose) polymerase-1 (PARP-1) is the principal member of the PARP enzyme
family consisting of PARP-1 and several recently identified novel poly(ADP-ribosyl)ating
enzymes. PARP-1 functions as a DNA damage sensor and signalling molecule. Upon ... Cited by 111 - Related articles - BL Direct - All 6 versions
L Zheng, C Szabó, TS Kern - Diabetes, 2004 - Am Diabetes Assoc The current study investigated the role of poly(ADP-ribose) polymerase (PARP) in the development
of diabetic retinopathy. Activity of PARP was increased in whole retina and in endothelial cells
and pericytes of diabetic rats. Administration of PJ-34 (a potent PARP inhibitor) for 9 ... Cited by 98 - Related articles - BL Direct - All 5 versions
- ►ahajournals.org C Szabo, A Zanchi, K Komjati, P Pacher, AS Krolewski, … - Circulation, 2002 - Am Heart Assoc Methods and Results— We included a control group of 21 healthy subjects, a group of 22 healthy
individuals with parental history of type 2 diabetes, a group of 23 subjects with impaired glucose
tolerance, and a group of 21 type 2 diabetic patients. Two 2-mm forearm skin biopsies ... Cited by 90 - Related articles - BL Direct - All 11 versions
- ►nih.gov [PDF] P Pacher, R Schulz, L Liaudet, C Szabó - Trends in Pharmacological Sciences, 2005 - Elsevier Dysregulation of nitric oxide (NO) and increased oxidative and nitrosative stress are implicated
in the pathogenesis of heart failure. Peroxynitrite is a reactive oxidant that is produced from the
reaction of nitric oxide with superoxide anion and impairs cardiovascular function through ... Cited by 90 - Related articles - All 9 versions
IG Obrosova, F Li, OI Abatan, MA Forsell, K Komjáti, P … - Diabetes, 2004 - Am Diabetes Assoc Oxidative and nitrosative stress play a key role in the pathogenesis of diabetic neuropathy, but
the mechanisms remain unidentified. Here we provide evidence that poly(ADP-ribose) polymerase
(PARP) activation, a downstream effector of oxidant-induced DNA damage, is an ... Cited by 88 - Related articles - BL Direct - All 10 versions
