- ►harvard.edu [PDF] CE Larsen, CA Alper - Current opinion in immunology, 2004 - Elsevier Type 1 diabetes mellitus (T1D) remains the most intensively studied, and thus the best
paradigm, of MHC-associated diseases. Accumulating evidence suggests that MHC susceptibility
for T1D is recessive, with susceptibility alleles more common than protective alleles. ... Cited by 60 - Related articles - All 4 versions
A Imagawa, T Hanafusa, Y Uchigata, A Kanatsuka, E … - Diabetologia, 2005 - Springer Page 1. Diabetologia (2005) 48: 294–300 DOI 10.1007/s00125-004-1626-x ARTICLE
A. Imagawa . T. Hanafusa . Y. Uchigata . A. Kanatsuka . E. Kawasaki . T. Kobayashi .
A. Shimada . I. Shimizu . T. Maruyama . H. Makino Different ... Cited by 58 - Related articles - BL Direct - All 4 versions
A Ide, E Kawasaki, N Abiru, F Sun, M Kobayashi, T … - Journal of Autoimmunity, 2004 - Elsevier Interleukin-18 (IL-18) is a potent proinflammatory cytokine which is strongly associated with the
development of diabetes in NOD mice. To test the putative involvement of IL-18 gene polymorphism
in predisposition to human type 1 diabetes, the SNPs at position –607 (C/A) and –137 ... Cited by 54 - Related articles - All 4 versions
R Gianani, GS Eisenbarth - Immunological reviews, 2005 - interscience.wiley.com Summary: Type 1A diabetes is a chronic autoimmune disease usually preceded by a long prodrome
during which autoantibodies to islet autoantigens are present. These antibodies are directed
to a variety of antigens, but the best characterized are glutamic acid decarboxylase-65, ... Cited by 42 - Related articles - All 4 versions
MMA Fernando, CR Stevens, EC Walsh, PL De … - PLOS …, 2008 - pubmedcentral.nih.gov The major histocompatibility complex (MHC) is one of the most extensively studied regions in
the human genome because of the association of variants at this locus with autoimmune,
infectious, and inflammatory diseases. However, identification of causal variants within ... Cited by 44 - Related articles - All 8 versions
S Murao, H Makino, Y Kaino, E Konoue, J Ohashi, K … - Diabetes, 2004 - Am Diabetes Assoc To clarify heterogeneity in Japanese adult-onset type 1 diabetes, we analyzed the HLA-DR and
-DQ haplotypes, depending on the clinical phenotype, and compared them with those in
childhood-onset type 1 diabetes (CO). The patients in a previously reported Ehime Study ... Cited by 36 - Related articles - BL Direct - All 4 versions
R Hermann, H Turpeinen, AP Laine, R Veijola, M … - Tissue …, 2003 - interscience.wiley.com Abstract: The diabetes predisposing effect of HLA genes is defined by a complex interaction
of various haplotypes. We analyzed the disease association of HLA DRB1-DQA1-DQB1 genotypes
in a large nuclear family cohort (n = 622) collected in Finland. Using the affected family ... Cited by 34 - Related articles - BL Direct - All 5 versions
- ►endojournals.org H Ikegami, T Awata, E Kawasaki, T Kobayashi, … - Journal of Clinical …, 2006 - Endocrine Soc Context: Transracial studies are a powerful tool for genetic association studies of multifactorial
diseases, such as type 1 diabetes. The low incidence of type 1 diabetes in Asian countries,
however, makes it difficult to perform large-scale studies in Asia. Cited by 34 - Related articles - BL Direct - All 4 versions
G Thomson, AM Valdes, JA Noble, I Kockum, MN … - Tissue …, 2007 - interscience.wiley.com The direct involvement of the human leukocyte antigen class II DR-DQ genes in type 1 diabetes
(T1D) is well established, and these genes display a complex hierarchy of risk effects at the genotype
and haplotype levels. We investigated, using data from 38 studies, whether the DR-DQ ... Cited by 30 - Related articles - All 5 versions
E Kawasaki, N Matsuura, K Eguchi - Diabetologia, 2006 - Springer Abstract Type 1 diabetes is a multifactorial disease which results from a T-cell-mediated autoimmune
destruction of the pancreatic beta cells in genetically predisposed individuals. The risk for individuals
of developing type 1 diabetes varies remarkably according to country of residence and ... Cited by 28 - Related articles - BL Direct - All 3 versions
