S Havelund, A Plum, U Ribel, I Jonassen, A … - Pharmaceutical research, 2004 - Springer The peptide hormone, insulin, is produced and stored in pancreatic beta-cells.
An adaptation of beta-cell insulin pro- duction is the assembly of insulin
molecules at high concen- tration in the presence of zinc ions into ... Cited by 94 - Related articles - BL Direct - All 3 versions
P Kurtzhals - International Journal of Obesity, 2004 - nature.com The suboptimal nature of the absorption profiles of human insulin formulations
following subcutaneous administration has prompted the development of insulin
analogues better suited for therapeutic use in diabetes mellitus. A ... Cited by 65 - Related articles - BL Direct - All 5 versions
P Home, P Kurtzhals - Expert Opin. Pharmacother., 2006 - Informa Pharma Science Insulin detemir (Levemir®, Novo Nordisk) is a novel, biologically engineered
analogue of human insulin that has been successfully developed for clinical use
in diabetes as a basal insulin. Its unique mechanism of prolongation of ... Cited by 58 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org M Sjöstrand, S Gudbjörnsdottir, A Holmäng, L … - Diabetes, 2002 - Am Diabetes Assoc Insulin-resistant subjects have a slow onset of insulin action, and the
underlying mechanism has not been determined. To evaluate whether a delayed
transcapillary transport is part of the peripheral insulin resistance, we ... Cited by 40 - Related articles - BL Direct - All 5 versions
- ►endojournals.org S Gudbjornsdottir, M Sjostrand, L Strindberg, … - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc PS for glucose increased significantly from 0.29 ± 0.1 to 0.64 ± 0.2
ml/min·100 g after oral glucose tolerance test, and glucose uptake increased
from 1.2 ± 0.4 to 2.6 ± 0.6 µmol/min·100 g (P < 0.05). During one-step ... Cited by 28 - Related articles - BL Direct - All 4 versions
M Ellmerer, M Hamilton-Wessler, SP Kim, K … - Diabetes, 2006 - Am Diabetes Assoc Physiological hyperinsulinemia provokes hemodynamic actions and augments access
of macromolecules to insulin-sensitive tissues. We investigated whether
induction of insulin resistance by a hypercaloric high-fat diet has an ... Cited by 19 - Related articles - BL Direct - All 5 versions
- ►physiology.org H Wang, Z Liu, G Li, EJ Barrett - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc The pathways by which insulin exits the vasculature to muscle interstitium have
not been characterized. In the present study, we infused FITC-labeled insulin to
trace morphologically (using confocal immunohistochemical methods) insulin ... Cited by 12 - Related articles - BL Direct - All 4 versions
P Kurtzhals - Diabetes and Metabolism, 2005 - Elsevier The development of insulin analogues over the last two decades have aimed at
optimising the pharmacokinetic profile of subcutaneously injected insulin for
therapeutic use in diabetes mellitus. Rapid acting analogues were ... Cited by 11 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org M Ellmerer, SP Kim, M Hamilton-Wessler, K … - Diabetes, 2004 - Am Diabetes Assoc Pharmacological doses of insulin increase limb blood flow and enhance tissue
recruitment for small solutes such as glucose. We investigated whether elevating
insulin within the physiological range (68 ± 6 vs. 425 ± 27 pmol/l) can ... Cited by 11 - Related articles - BL Direct - All 4 versions
DR Owens, GB Bolli - Diabetes Technology & Therapeutics, 2008 - liebertonline.com The new rDNA and DNA-derived “basal” insulin analogs, glargine and detemir,
represent significant ad- vancement in the treatment of diabetes compared with
conventional NPH insulin. This review describes blood glucose homeostasis ... Cited by 7 - Related articles - All 3 versions
