- ►diabetesjournals.org J Tonelli, W Li, P Kishore, UB Pajvani, E … - Diabetes, 2004 - Am Diabetes Assoc Whereas thiazolidinediones (TZDs) are known to rapidly improve insulin action in
animals, short durations of TZD therapy have never been studied in humans. Among
the many known actions of TZDs, increased circulating levels of the high ... Cited by 143 - Related articles - BL Direct - All 5 versions
PJ Havel - Nutrition reviews, 2005 - ingentaconnect.com Fructose intake and the prevalence of obesity have both increased over the past
two to three decades. Compared with glucose, the hepatic metabolism of fructose
favors lipogenesis, which may contribute to hyperlipidemia and obesity. ... Cited by 127 - Related articles - All 8 versions
KJ Brocklehurst, VA Payne, RA Davies, D … - Diabetes, 2004 - Am Diabetes Assoc Glucokinase (GK) has a major role in the control of blood glucose homeostasis
and is a strong potential target for the pharmacological treatment of type 2
diabetes. We report here the mechanism of action of two novel and potent ... Cited by 76 - Related articles - BL Direct - All 6 versions
- ►endojournals.org AM Efanov, DG Barrett, MB Brenner, SL Briggs … - Endocrinology, 2005 - Endocrine Soc The glucose-sensing enzyme glucokinase (GK) plays a key role in glucose
metabolism. We report here the effects of a novel glucokinase activator,
LY2121260. The activator enhanced GK activity via binding to the allosteric ... Cited by 56 - Related articles - BL Direct - All 5 versions
OP McGuinness, AD Cherrington - Current Opinion in Clinical Nutrition & Metabolic Care, 2003 - journals.lww.com Recent findings: Catalytic quantities of fructose (<10% of total carbohydrate
flux) enhance liver glucose uptake in a dose dependent manner. The primary fate
of the glucose is glycogen synthesis. The ability of fructose to augment ... Cited by 40 - Related articles - BL Direct - All 2 versions
- ►physiology.org SR Commerford, JB Ferniza, ME Bizeau, JS … - American Journal of Physiology- Endocrinology And …, 2002 - Am Physiological Soc High-fat (HFD) and high-sucrose diets (HSD) reduce insulin suppression of
glucose production in vivo, increase the capacity for gluconeogenesis in vitro,
and increase glucose-6-phosphatase (G-6-Pase) activity in whole cell ... Cited by 25 - Related articles - BL Direct - All 5 versions
MC Moore, AD Cherrington, DH Wasserman - Best Practice & Research Clinical Endocrinology & …, 2003 - Elsevier Precise regulation of hepatic and peripheral glucose uptake is essential to
preserve glucose homeostasis. The liver extracts 1/3 of an oral glucose load,
skeletal muscle extracts 1/3, and other tissues, particularly the central ... Cited by 19 - Related articles - All 6 versions
- ►nih.gov [PDF] S Aiston, A Green, M Mukhtar, L Agius - Biochemical Journal, 2004 - pubmedcentral.nih.gov The role of glucose 6-P (glucose 6-phosphate) in regulating the activation state
of glycogen synthase and its translocation is well documented. In the present
study, we investigated the effects of glucose 6-P on the activation state ... Cited by 16 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org Y Fujimoto, TP Torres, EP Donahue, M Shiota - Diabetes, 2006 - Am Diabetes Assoc The effect of restoration of normoglycemia by a novel sodium-dependent glucose
transporter inhibitor (T-1095) on impaired hepatic glucose uptake was examined
in 14-week-old Zucker diabetic fatty (ZDF) rats. The nontreated group ... Cited by 14 - Related articles - BL Direct - All 5 versions
I Gabriely, H Shamoon - Diabetes, 2005 - Am Diabetes Assoc We have previously reported that specific counterregulatory responses to
hypoglycemia were augmented by an infusion of fructose in nondiabetic humans. We
hypothesized that this effect was due to the interaction of a ... Cited by 13 - Related articles - All 6 versions
