- ►jimmunol.org L Strauss, TL Whiteside, A Knights, C … - The Journal of Immunology, 2007 - Am Assoc Immnol Naturally occurring CD4 + CD25 + regulatory T (nTreg) cells are essential for
maintaining T cell tolerance to self Ags. We show that discrimination of human
Treg from effector CD4 + CD25 + non-nTreg cells and their selective ... Cited by 97 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org M Battaglia, A Stabilini, E Draghici, S … - Diabetes, 2006 - Am Diabetes Assoc Islet transplantation is a cure for type 1 diabetes, but its potential is
limited by the need for constant immunosuppression. One solution to this problem
is the induction of transplantation tolerance mediated by T regulatory ... Cited by 75 - Related articles - BL Direct - All 6 versions
- ►nih.gov Q Tang, JY Adams, C Penaranda, K Melli, E … - Immunity, 2008 - Elsevier The dynamics of CD4 + effector T cells (Teff cells) and CD4 + Foxp3 + regulatory
T cells (Treg cells) during diabetes progression in nonobese diabetic mice was
investigated to determine whether an imbalance of Treg cells and Teff cells ... Cited by 53 - Related articles - All 7 versions
- ►shouxi.net M Battaglia, A Stabilini, E Draghici, B … - Diabetes, 2006 - Am Diabetes Assoc Success in developing novel therapies to recommence self-tolerance in
autoimmunity depends on the induction of T regulatory (Tr) cells. Here, we
report that rapamycin combined with interleukin (IL)-10 efficiently blocks ... Cited by 47 - Related articles - BL Direct - All 5 versions
T Staeva-Vieira, M Peakman, M Von Herrath - Clinical and Experimental Immunology, 2007 - pubmedcentral.nih.gov Type 1 diabetes (T1D) is often considered the prototype organ-specific
autoimmune disease in clinical immunology circles. The key disease features −
precise destruction of a single endocrine cell type occurring on a distinct ... Cited by 47 - Related articles - BL Direct - All 5 versions
M Cetkovic-Cvrlje, AL Dragt, A Vassilev, XP … - Clinical Immunology, 2003 - Elsevier Here we show that Janus kinase (JAK) 3 is an important molecular target for
treatment of autoimmune insulin-dependent (type 1) diabetes mellitus. The
rationally designed JAK3 inhibitor JANEX-1 exhibited potent ... Cited by 40 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org H Hui, N Khoury, X Zhao, L Balkir, ED'Amico, A … - Diabetes, 2005 - Am Diabetes Assoc Immunosuppressive drugs are routinely used to provide tolerance after whole
pancreas and islet cell transplantations. While they are essential in inhibiting
graft rejection, little is known about their effect on islet function and ... Cited by 32 - Related articles - All 5 versions
- ►171.66.122.149 Y Fujitani, A Trifilieff - American journal of respiratory and critical care …, 2003 - 171.66.122.149 No current therapy is considered to be satisfactory for severe asthma, and
alternative approaches are still required for what is a major unmet medical
need. In this study, we compared the effect of a rapamycin derivative, SAR ... Cited by 30 - Related articles - BL Direct - All 7 versions
T Brusko, A Putnam, J Bluestone - Immunological Reviews, 2008 - interscience.wiley.com SummaryThe importance of regulatory T lymphocytes (Tregs) in the control of
autoimmunity is now well established in a variety of experimental animal models.
In addition, there are numerous studies suggesting that Treg deficits may ... Cited by 31 - Related articles - All 4 versions
- ►inotekcorp.com [PDF] WL Suarez-Pinzon, JG Mabley, R Power, C … - Diabetes, 2003 - Am Diabetes Assoc Poly (ADP-ribose) polymerase (PARP) is a nuclear enzyme that consumes NAD in
response to DNA strand breaks. The PARP inhibitor nicotinamide prevents NAD
consumption and protects islet β-cells from chemically induced necrosis ... Cited by 28 - Related articles - BL Direct - All 9 versions
