- ►diabetesjournals.org DJ Drucker - Diabetes Care, 2003 - Am Diabetes Assoc RESULTS—Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide
(GIP) exert important effects on β-cells to stimulate glucose-dependent insulin secretion. Both
peptides also regulate β-cell proliferation and cytoprotection. GLP-1, but not GIP, inhibits ... Cited by 284 - Related articles - All 13 versions
- ►aspetjournals.org KE Mayo, LJ Miller, D Bataille, S Dalle, B Goke, B … - Pharmacological reviews, 2003 - ASPET Peptide hormones within the secretin-glucagon family are expressed in endocrine cells of the
pancreas and gastrointestinal epithelium and in specialized neurons in the brain, and subserve
multiple biological functions, including regulation of growth, nutrient intake, and transit ... Cited by 143 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org JA Pospisilik, SG Stafford, HU Demuth, CHS McIntosh, … - Diabetes, 2002 - Am Diabetes Assoc Upon release into circulation, the potent insulin secretagogues glucose-dependent insulinotropic
polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are rapidly cleaved and inactivated by
the enzyme dipeptidyl peptidase IV (DP IV). Long-term administration of specific DP IV ... Cited by 99 - Related articles - BL Direct - All 6 versions
- ►endocrinology-journals.org [PDF] VA Gault, JC Parker, P Harriott, PR Flatt, FP … - Journal of …, 2002 - Soc Endocrinology The incretin hormone glucose-dependent insulinotropic polypeptide (GIP) is rapidly degraded
in the circulation by dipeptidyl peptidase IV forming the N-terminally truncated peptide
GIP(3–42). The present study exam- ined the biological activity of this abundant ... Cited by 57 - Related articles - BL Direct - All 5 versions
- ►diabetica.co.uk [PDF] VA Gault, PR Flatt, FPM O'Harte - Biochemical and Biophysical Research …, 2003 - Elsevier Glucose-dependent insulinotropic polypeptide (GIP) is a key incretin hormone, released postprandially
into the circulation in response to feeding, producing a glucose-dependent stimulation of insulin
secretion. It is this glucose-dependency that has attracted attention towards GIP as a ... Cited by 55 - Related articles - All 7 versions
- ►diabetica.co.uk [PDF] VA Gault, FPM O'Harte, PR Flatt - Neuropeptides, 2003 - Elsevier Glucose-dependent insulinotropic polypeptide (GIP or gastric inhibitory polypeptide) is a gastrointestinal
hormone, which modulates physiological insulin secretion. Due to its insulinotropic activity, there
has been a considerable increase of interest in utilising the hormone as a potential ... Cited by 53 - Related articles - All 10 versions
- ►adisonline.com [PDF] JJ Meier, B Gallwitz, MA Nauck - BioDrugs, 2003 - ingentaconnect.com Abstract Although the insulinotropic actions of gastric inhibitory polypeptide (GIP) and
glucagon-like peptide 1 (GLP-1) have been known for almost 2 decades, the incretin hormones
have not yet become available for clinical application. This can be explained by their ... Cited by 47 - Related articles - BL Direct - All 5 versions
- ►diabetica.co.uk [PDF] BD Green, VA Gault, FPM O'Harte, PR … - Current pharmaceutical …, 2004 - ingentaconnect.com Abstract: Glucagon-like peptide-1(7-36)amide (GLP-1) and glucose-dependent insulinotropic
polypeptide (GIP) are gastrointestinal insulin-releasing hormones involved in the regulation of
postprandial nutrient homeostasis. These two incretin hormones are glucose-dependent ... Cited by 46 - Related articles - BL Direct - All 9 versions
- ►endocrinology-journals.org [PDF] VA Gault, PR Flatt, P Harriott, MH Mooney, … - Journal of …, 2003 - Soc Endocrinology The therapeutic potential of glucagon-like peptide-1 (GLP-1) in improving glycaemic control in
diabetes has been widely studied, but the potential beneficial effects of glucose-dependent insulinotropic
polypeptide (GIP) have until recently been almost overlooked. One of the major problems, ... Cited by 25 - Related articles - BL Direct - All 8 versions
SA Hinke, K Hellemans, FC Schuit - The Journal of physiology, 2004 - Physiological Soc It is well established that the acute rise in plasma glucose and in the incretin hormones
glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (7–36) amide
(GLP-1), as occurs during a meal, is of pivotal importance in regulating the ... Cited by 26 - Related articles - All 9 versions
