- ►endojournals.org JL Evans, ID Goldfine, BA Maddux, GM … - Endocrine Reviews, 2002 - Endocrine Soc In both type 1 and type 2 diabetes, the late diabetic complications in nerve,
vascular endothelium, and kidney arise from chronic elevations of glucose and
possibly other metabolites including free fatty acids (FFA). Recent ... Cited by 591 - Related articles - BL Direct - All 18 versions
- ►endojournals.org V Poitout, RP Robertson - Endocrinology, 2002 - Endocrine Soc Chronic hyperglycemia and hyperlipidemia can exert deleterious effects on
ß-cell function, respectively referred to as glucotoxicity and lipotoxicity.
Over time, both contribute to the progressive deterioration of glucose ... Cited by 328 - Related articles - BL Direct - All 4 versions
RP Robertson, J Harmon, POT Tran, V Poitout - Diabetes, 2004 - Am Diabetes Assoc The relentless decline in β-cell function frequently observed in type 2
diabetic patients, despite optimal drug management, has variously been
attributed to glucose toxicity and lipotoxicity. The former theory posits ... Cited by 202 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org M Cnop, N Welsh, JC Jonas, A Jörns, S Lenzen … - Diabetes, 2005 - Am Diabetes Assoc Type 1 and type 2 diabetes are characterized by progressive β-cell failure.
Apoptosis is probably the main form of β-cell death in both forms of the
disease. It has been suggested that the mechanisms leading to nutrient- and ... Cited by 169 - Related articles - BL Direct - All 10 versions
JW Joseph, V Koshkin, CY Zhang, J Wang, … - Diabetes, 2002 - Am Diabetes Assoc Uncoupling protein 2 (UCP2) may act as an important regulator of insulin
secretion. In this study, β-cell function in UCP2-deficient mice was examined
after a 45% high-fat diet (HFD) to assess its role during the development ... Cited by 119 - Related articles - BL Direct - All 5 versions
- ►pubget.com [PDF] DR Laybutt, AM Preston, MC Åkerfeldt, JG … - Diabetologia, 2007 - Springer Page 1. ARTICLE Endoplasmic reticulum stress contributes to beta cell apoptosis
in type 2 diabetes DR Laybutt & AM Preston & MC Åkerfeldt & ... Cited by 103 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org CB Chan, MC Saleh, V Koshkin, MB Wheeler - Diabetes, 2004 - Am Diabetes Assoc Stressors such as chronic hyperglycemia or hyperlipidemia may lead to
insufficient insulin secretion in susceptible individuals, contributing to type
2 diabetes. The molecules mediating this effect are just beginning to be ... Cited by 83 - Related articles - BL Direct - All 4 versions
M Faraj, HL Lu, K Cianflone - Biochemistry and Cell Biology, 2004 - article.pubs.nrc-cnrc.gc.ca Abstract: That obesity is associated with insulin resistance and type II
diabetes mellitus is well accepted. Overloading of white adipose tissue beyond
its storage capacity leads to lipid disorders in non-adipose tissues, ... Cited by 78 - Related articles - BL Direct - All 7 versions
- ►endojournals.org V Poitout, RP Robertson - Endocrine reviews, 2008 - Endocrine Soc Glucotoxicity, lipotoxicity, and glucolipotoxicity are secondary phenomena that
are proposed to play a role in all forms of type 2 diabetes. The underlying
concept is that once the primary pathogenesis of diabetes is established, ... Cited by 68 - Related articles - BL Direct - All 7 versions
B Wicksteed, C Alarcon, I Briaud, MK Lingohr … - Journal of Biological Chemistry, 2003 - ASBMB Proinsulin biosynthesis is regulated in response to nutrients, most notably
glucose. In the short term ( 2h) this is due to increases in the translation of
pre-existing mRNA. However, prolonging glucose stimulation (24 h) also ... Cited by 61 - Related articles - BL Direct - All 4 versions
