- ►physiology.org JJ Holst - Physiological reviews, 2007 - Am Physiological Soc Glucagon-like peptide 1 (GLP-1) is a 30-amino acid peptide hormone produced in
the intestinal epithelial endocrine L-cells by differential processing of
proglucagon, the gene which is expressed in these cells. The current ... Cited by 113 - Related articles - BL Direct - All 5 versions
- ►aspetjournals.org ME Doyle, JM Egan - Pharmacological reviews, 2003 - ASPET Blood glucose levels are sensed and controlled by the release of hormones from
the islets of Langerhans in the pancreas. The -cell, the insulin-secreting cell
in the islet, can detect subtle increases in circulating glucose levels and ... Cited by 80 - Related articles - BL Direct - All 8 versions
JJ Heit, ÅA Apelqvist, X Gu, MM Winslow, JR … - Nature, 2006 - nature.com The growth and function of organs such as pancreatic islets adapt to meet
physiological challenges and maintain metabolic balance, but the mechanisms
controlling these facultative responses are unclear 1, 2 . Diabetes in ... Cited by 68 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org F Schuit, D Flamez, A De Vos, D Pipeleers - Diabetes, 2002 - Am Diabetes Assoc The mammalian β-cell has particular properties that synthesize, store, and
secrete insulin in quantities that are matched to the physiological demands of
the organism. To achieve this task, β-cells are regulated both acutely and ... Cited by 55 - Related articles - BL Direct - All 5 versions
- ►cyclicamp.ca [PDF] D Delmeire, D Flamez, SA Hinke, JJ Cali, D … - Diabetologia, 2003 - Springer Aims/hypothesis. The secretory function of pancreatic beta cells is
synergistically stimulated by two signalling pathways which mediate the effects
of nutrients and hormones such as glucagon-like peptide 1 (GLP-1), glucose- ... Cited by 43 - Related articles - BL Direct - All 4 versions
- ►jbc.org MC Lawrence, K McGlynn, BH Park, MH Cobb - Journal of Biological Chemistry, 2005 - ASBMB The insulin promoter is both positively and negatively regulated in response to
conditions to which pancreatic -cells are exposed. Exposure of intact rat islets
and INS-1 pancreatic -cells to 11 mM glucose for minutes to hours results ... Cited by 35 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org E Oetjen, D Baun, S Beimesche, D Krause, I … - Molecular pharmacology, 2003 - ASPET Cyclosporin A and tacrolimus are clinically important immunosuppressive drugs.
They share a diabetogenic action as one of their most serious adverse effects.
The underlying mechanism is unknown. Previous studies have shown that ... Cited by 34 - Related articles - BL Direct - All 3 versions
- ►physiology.org EM Sinclair, DJ Drucker - Physiology, 2005 - Am Physiological Soc The proglucagon-derived peptides (PGDPs) are encoded by a single mammalian
proglucagon gene. Tissue-specific posttranslational processing mediated by
prohormone convertase (PC) enzymes liberates these peptide hormones in a ... Cited by 29 - Related articles - All 4 versions
PF Mora - The American journal of the medical sciences, 2005 - journals.lww.com Transplantation medicine has grown to be a daily part of today's medical
practice, and with the introduction of modern immunosuppression agents and
protocols, improvements in graft survival have been achieved. The metabolic ... Cited by 25 - Related articles - All 5 versions
