- ►nih.gov R Bertram, L Satin, M Zhang, P Smolen, A Sherman - Biophysical journal, 2004 - Elsevier Pancreatic islets of Langerhans produce bursts of electrical activity when exposed to stimulatory
glucose levels. These bursts often have a regular repeating pattern, with a period of 10–60
s. In some cases, however, the bursts are episodic, clustered into bursts of bursts, which ... Cited by 46 - Related articles - BL Direct - All 15 versions
- ►nih.gov PO Westermark, A Lansner - Biophysical Journal, 2003 - Elsevier We have constructed a model of the upper part of the glycolysis in the pancreatic β-cell. The
model comprises the enzymatic reactions from glucokinase to glyceraldehyde-3-phosphate dehydrogenase
(GAPD). Our results show, for a substantial part of the parameter space, an oscillatory ... Cited by 33 - Related articles - BL Direct - All 11 versions
CS Nunemaker, M Zhang, DH Wasserman, OP … - Diabetes, 2005 - Am Diabetes Assoc Pulsatile insulin secretion in vivo is believed to be derived, in part, from the intrinsic
glucose-dependent intracellular calcium concentration ([Ca 2+ ] i ) pulsatility of individual
islets. In isolation, islets display fast, slow, or mixtures of fast and slow [Ca 2+ ] i ... Cited by 24 - Related articles - BL Direct - All 10 versions
- ►physiology.org R Buettner, I Ottinger, J Scholmerich, LC … - American Journal of …, 2004 - Am Physiological Soc Recent in vivo studies have demonstrated a strong negative correlation between liver triglyceride
content and hepatic insulin sensitivity, but a causal relationship remains to be established. We
therefore have examined parameters of direct hepatic insulin action on isolated steatotic ... Cited by 18 - Related articles - BL Direct - All 4 versions
- ►physiology.org R Bertram, A Sherman, LS Satin - American Journal of Physiology …, 2007 - Am Physiological Soc Impairment of insulin secretion from the -cells of the pancreatic islets of Langerhans is central
to the development of type 2 diabetes mellitus and has therefore been the subject of much
investigation. Great advances have been made in this area, but the mechanisms ... Cited by 19 - Related articles - BL Direct - All 7 versions
- ►nih.gov CS Nunemaker, R Bertram, A Sherman, K Tsaneva- … - Biophysical journal, 2006 - Elsevier Pancreatic islets of Langerhans display complex intracellular calcium changes in response to
glucose that include fast (seconds), slow ( 5 min), and mixed fast/slow oscillations; the slow and
mixed oscillations are likely responsible for the pulses of plasma insulin observed in vivo. ... Cited by 16 - Related articles - BL Direct - All 15 versions
- ►nih.gov K Tsaneva-Atanasova, CL Zimliki, R Bertram, A … - Biophysical journal, 2006 - Elsevier Cell coupling is important for the normal function of the β-cells of the pancreatic islet of
Langerhans, which secrete insulin in response to elevated plasma glucose. In the islets, electrical
and metabolic communications are mediated by gap junctions. Although electrical ... Cited by 12 - Related articles - BL Direct - All 21 versions
- ►nih.gov R Bertram, LS Satin, MG Pedersen, DS Luciani, A … - Biophysical journal, 2007 - Elsevier Insulin secretion from pancreatic β-cells is oscillatory, with a typical period of 2–7 min, reflecting
oscillations in membrane potential and the cytosolic Ca 2+ concentration. Our central hypothesis
is that the slow 2–7 min oscillations are due to glycolytic oscillations, whereas faster ... Cited by 10 - Related articles - BL Direct - All 17 versions
- ►nih.gov [PDF] IZ Zubrzycki - Biophysical journal, 2002 - Elsevier Sleeping sickness and Chagas disease are among the most severe diseases in Africa as well
as Latin America. These two diseases are caused by Trypanosoma spp. Recently, an enzyme
of a glycolytic pathway, NAD-dependent glycerol-3-phosphate dehydrogenase, of ... Cited by 7 - Related articles - BL Direct - All 11 versions
PO Carlsson, L Jansson, F Palm - Acta Physiologica …, 2002 - interscience.wiley.com The present study investigated the importance of a tightly regulated islet blood flow for an optimal
oxygenation of the islet tissue during different demands for insulin release. Glucose and/or a
non-specific nitric oxide synthase inhibitor (l-NNA) were infused intravenously in non- ... Cited by 6 - Related articles - BL Direct - All 4 versions
