- ►endojournals.org H Bays, L Mandarino, RA DeFronzo - Journal of Clinical Endocrinology & …, 2004 - Endocrine Soc Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance in liver and muscle and
impaired insulin secretion. Considerable evidence also implicates deranged adipocyte metabolism
and altered fat topography in the pathogenesis of glucose intolerance in T2DM. 1) Fat ... Cited by 245 - Related articles - All 4 versions
- ►nih.gov RK Semple, VKK Chatterjee, SO' … - Journal of Clinical …, 2006 - Am Soc Clin Investig The nuclear receptor family of PPARs was named for the ability of the original member to induce
hepatic peroxisome proliferation in mice in response to xenobiotic stimuli. However, studies on
the action and structure of the 3 human PPAR isotypes (PPARα, PPARδ, and PPARγ) ... Cited by 243 - Related articles - BL Direct - All 10 versions
- ►endojournals.org H Motoshima, X Wu, MK Sinha, VE Hardy, EL … - Journal of Clinical …, 2002 - Endocrine Soc Adiponectin is an adipocyte-derived plasma protein with insulin-sensitizing and antiatherosclerotic
properties. Because adipose tissue depots differ in the strength of their association with the adverse
metabolic consequences of obesity, we studied the secretion of adiponectin in vitro from ... Cited by 218 - Related articles - BL Direct - All 4 versions
- ►endojournals.org M Gurnell, DB Savage, VKK Chatterjee, S O' … - Journal of Clinical …, 2003 - Endocrine Soc By the end of this decade, it has been estimated that between 200 million and 300 million people
worldwide will meet World Health Organization diagnostic criteria for diabetes mellitus. This epidemic
of predominantly type 2 diabetes has largely been mediated by our shift toward a more ... Cited by 130 - Related articles - BL Direct - All 5 versions
KA Virtanen, K Hällsten, R Parkkola, T Janatuinen, F … - Diabetes, 2003 - Am Diabetes Assoc We evaluated the effects of rosiglitazone (4 mg bid) and metformin (1 g bid) monotherapy for
26 weeks on adipose tissue insulin-stimulated glucose uptake in patients (n = 41) with type 2
diabetes. Before and after the treatment, glucose uptake was measured using 2-[ 18 ... Cited by 112 - Related articles - BL Direct - All 4 versions
- ►cell.com M Lafontan, M Berlan - Trends in pharmacological sciences, 2003 - Elsevier Obesity is an increasing health problem in many countries. Striking differences exist in the magnitude
of the impact of different obesities on comorbidities. Individuals with peripheral obesity
('pears') possess fat distributed subcutaneously in gluteofemoral areas and the lower part ... Cited by 109 - Related articles - All 7 versions
TM Larsen, S Toubro, A Astrup - International journal of obesity, 2003 - nature.com The nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPAR ) is
a member of the PPAR family. The endogenous activators of all members of the PPAR family
are a variety of fatty acids, which suggests that the PPARs are highly involved in lipid ... Cited by 108 - Related articles - BL Direct - All 5 versions
JR Seckl, NM Morton, KE Chapman, BR … - Recent progress in …, 2004 - Endocrine Soc The highly prevalent metabolic syndrome (insulin resistance, type 2 diabetes, dyslipidemia,
hypertension, along with abdominal obesity) resembles Cushing's syndrome. However, in simple
obesity, plasma cortisol levels are not elevated. 11beta-hydroxysteroid dehydrogenase ... Cited by 99 - Related articles - BL Direct - All 2 versions
- ►oxfordjournals.org C Capanni, E Mattioli, M Columbaro, E … - Human Molecular …, 2005 - Oxford Univ Press Lipodystrophies are a heterogeneous group of human disorders characterized by the anomalous
distribution of body fat associated with insulin resistance and altered lipid metabolism. The pathogenetic
mechanism of inherited lipodystrophies is not yet clear; at the molecular level they have ... Cited by 66 - Related articles - All 8 versions
G Fruhbeck - Current Medicinal Chemistry-Cardiovascular & …, 2004 - ingentaconnect.com Abstract: Obesity is associated with increased incidence of cardiovascular mortality.
However, the mechanisms that link increased fat mass with hypercholesterolemia,
hypertension, endothelial dysfunction and coronary heart disease have not been fully ... Cited by 66 - Related articles - BL Direct - All 2 versions
