A Entingh-Pearsall, CR Kahn - Journal of Biological Chemistry, 2004 - ASBMB Insulin and insulin-like growth factor-I (IGF-I) receptors are highly homologous
tyrosine kinase receptors that share many common steps in their signaling
pathways and have ligands that can bind to either receptor with differing ... Cited by 54 - Related articles - BL Direct - All 5 versions
AM Valverde, M Benito, M Lorenzo… - Acta Physiologica Scandinavica, 2005 - med.uio.no Abstract Type 2 diabetes mellitus is a complex metabolic disease that occurs
when insulin secretion can no longer compensate insulin resistance in peripheral
tissues. At the molecular level, insulin resistance correlates with ... Cited by 41 - Related articles - View as HTML - All 4 versions
- ►jbc.org K Fulzele, DJ DiGirolamo, Z Liu, J Xu, JL … - Journal of Biological Chemistry, 2007 - ASBMB Defective bone formation is common in patients with diabetes, suggesting that
insulin normally exerts anabolic actions in bone. However, because insulin can
cross-activate the insulin-like growth factor type 1 receptor (IGF-1R), ... Cited by 15 - Related articles - All 4 versions
- ►endojournals.org C Mur, M Arribas, M Benito, AM Valverde - Endocrinology, 2003 - Endocrine Soc To define the specific role of IGF-I receptor (IGF-IR) in adipogenic and
thermogenic differentiation of brown adipocytes during late fetal life, we have
established immortalized brown adipocyte cell lines from fetuses of IGF-IR- ... Cited by 14 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org N Klöting, L Koch, T Wunderlich, M Kern, K … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Conditional IGF-1R inactivation resulted in increased adipose tissue
mass with a predominantly increased lipid accumulation in epigonadal fat pads.
However, insulin-stimulated glucose uptake into adipocytes was unaffected ... Cited by 11 - Related articles - All 5 versions
- ►physiology.org A Suryawan, TA Davis - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc The high activity of the insulin-signaling pathway contributes to the enhanced
feeding-induced stimulation of translation initiation in skeletal muscle of
neonatal pigs. Protein-tyrosine-phosphatase 1B (PTP1B) is a negative ... Cited by 10 - Related articles - BL Direct - All 4 versions
A Belfiore, F Frasca - Journal of mammary gland biology and neoplasia, 2008 - Springer Abstract Major molecular abnormalities in breast cancer include the deregulation
of several components of the IGF system. It is well recognized that the
epithelial breast cancer cells commonly overexpress the IGF-I receptor ... Cited by 7 - Related articles - All 3 versions
- ►molbiolcell.org AM Valverde, C Mur, M Brownlee, M Benito - Molecular biology of the cell, 2004 - Am Soc Cell Biol Fetal brown adipocytes are insulin-like growth factor-I (IGF-I) target cells. To
assess the importance of the IGF-I receptor (IGF-IR) in brown adipocytes during
fetal life, we have generated immortalized brown adipocyte cell lines from ... Cited by 8 - Related articles - BL Direct - All 6 versions
N Engberding, A San Martin, A Martin- … - Arteriosclerosis, Thrombosis, and Vascular Biology, 2009 - Am Heart Assoc Methods and Results— IGF1R expression was increased in aortas from diabetic
mice. IGF1R overexpression in VSMCs impaired insulin-induced Akt
phosphorylation. Conversely, IGF1R downregulation by siRNA allowed assembly ... Cited by 1 - Related articles - All 6 versions
JC Brüning, Z Straße, M Blüher, P Rosenthal- … - Am Diabetes Assoc 1 Department of Medicine, University of Leipzig, Leipzig, Germany 2 Department
of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne
and Center of Molecular Medicine Cologne (CMMC), Cologne, Germany 3 ... Related articles
