H Yki-Jarvinen - New England Journal of Medicine, 2004 - content.nejm.org Insulin resistance both precedes and predicts type 2 diabetes mellitus. 1 Although exercise and
weight loss ameliorate insulin resistance and may in some cases prevent or delay onset of the
disease, 2 therapy that combats insulin resistance in those who fail to change their ... Cited by 847 - Related articles - BL Direct - All 6 versions
- ►shouxi.net KF Petersen, S Dufour, D Befroy, R Garcia, … - The New England …, 2004 - nejm.highwire.org Methods We performed hyperinsulinemic–euglycemic clamp studies in combination with infusions
of [6,6- 2 H 2 ]glucose in healthy, young, lean, insulin-resistant offspring of patients with type
2 diabetes and insulin-sensitive control subjects matched for age, height, weight, and ... Cited by 786 - Related articles - BL Direct - All 14 versions
JD Browning, LS Szczepaniak, R Dobbins, P … - Hepatology, 2004 - interscience.wiley.com Despite the increasing prevalence of nonalcoholic fatty liver disease (NAFLD), its pathogenesis
and clinical significance remain poorly defined. In this study, we examined and compared the
distribution of hepatic triglyceride content (HTGC) in 2,287 subjects from a multiethnic, ... Cited by 532 - Related articles - All 3 versions
G Boden, GI Shulman - European Journal of Clinical …, 2002 - interscience.wiley.com Plasma free fatty acids (FFA) play important physiological roles in skeletal muscle, heart, liver
and pancreas. However, chronically elevated plasma FFA appear to have pathophysiological
consequences. Elevated FFA concentrations are linked with the onset of peripheral and ... Cited by 491 - Related articles - BL Direct - All 3 versions
K Promrat, G Lutchman, GI Uwaifo, RJ Freedman, A … - Hepatology, 2004 - hepatitis.cl Nonalcoholic steatohepatitis (NASH) is a common chronic liver disease for which there is no
known effective therapy. A proportion of patients with NASH progress to advanced fibrosis and
cirrhosis. NASH is considered one of the clinical features of the metabolic syndrome in ... Cited by 470 - Related articles - View as HTML - All 7 versions
JL Evans, ID Goldfine, BA Maddux, GM Grodsky - Diabetes, 2003 - Am Diabetes Assoc In both type 1 and type 2 diabetes, diabetic complications in target organs arise from chronic
elevations of glucose. The pathogenic effect of high glucose, possibly in concert with fatty
acids, is mediated to a significant extent via increased production of reactive oxygen ... Cited by 371 - Related articles - BL Direct - All 10 versions
- ►nih.gov KF Petersen, EA Oral, S Dufour, D Befroy, … - Journal of Clinical …, 2002 - Am Soc Clin Investig Lipodystrophy is a rare disorder that is characterized by selective loss of subcutaneous and visceral
fat and is associated with hypertriglyceridemia, hepatomegaly, and disordered glucose
metabolism. It has recently been shown that chronic leptin treatment ameliorates these ... Cited by 350 - Related articles - BL Direct - All 10 versions
M Tiikkainen, AM Häkkinen, E Korsheninnikova, T … - Diabetes, 2004 - Am Diabetes Assoc Both rosiglitazone and metformin increase hepatic insulin sensitivity, but their mechanism of
action has not been compared in humans. The objective of this study was to compare the effects
of rosiglitazone and metformin treatment on liver fat content, hepatic insulin sensitivity, ... Cited by 280 - Related articles - BL Direct - All 6 versions
B Staels, JC Fruchart - Diabetes, 2005 - Am Diabetes Assoc Peroxisome proliferator–activated receptors (PPARs) play key roles in the regulation of energy
homeostasis and inflammation, and agonists of PPARα and -γ are currently used
therapeutically. Fibrates, first used in the 1970s for their lipid-modifying properties, were ... Cited by 269 - Related articles - BL Direct - All 10 versions
MR Taskinen - Diabetologia, 2003 - Springer The recognition that the increase of plasma triglyce- ride rich lipoproteins (TRLs) is associated
with multi- ple alterations of other lipoproteins species that are potentially atherogenic has expanded
the picture of diabetic dyslipidaemia. The discovery of heterogene- ity within major ... Cited by 251 - Related articles - BL Direct - All 7 versions
