- ►asnjournals.org MD Breyer, E Bottinger, FC Brosius III, TM … - Journal of the American Society of Nephrology, 2005 - Am Soc Nephrol Mice provide an experimental model of unparalleled flexibility for studying
mammalian diseases. Inbred strains of mice exhibit substantial differences in
their susceptibility to the renal complications of diabetes. Much remains ... Cited by 104 - Related articles - All 6 versions
- ►oxfordjournals.org MI McCarthy - Human Molecular Genetics, 2004 - Oxford Univ Press The rapid increase in the prevalence of type 2 diabetes (T2D) represents a major
challenge for health care delivery worldwide. Identification of genes
influencing individual susceptibility to disease offers a route to better ... Cited by 94 - Related articles - All 4 versions
- ►diabetesjournals.org M Rossmeisl, JS Rim, RA Koza, LP Kozak - Diabetes, 2003 - Am Diabetes Assoc C57BL/6J (B6) and AKR/J (AKR) inbred strains of mice develop a comparable degree
of obesity when fed a high-fat diet. However, although obese B6 mice are more
glucose intolerant, obese AKR mice are more insulin resistant. To ... Cited by 64 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org K Almind, CR Kahn - Diabetes, 2004 - Am Diabetes Assoc Diet-induced obesity is the primary determinant of the current epidemic of
diabetes. We have explored the role of genetics in this phenomenon, using
C57Bl/6 (B6), 129S6/SvEvTac (129), and intercross (B6 × 129)F2 mice on a ... Cited by 54 - Related articles - BL Direct - All 6 versions
- ►ahajournals.org Y Hu, D Belke, J Suarez, E Swanson, R Clark … - Circulation research, 2005 - Am Heart Assoc To examine whether excessive protein O-GlcNAcylation plays a role in the
dysfunction of the diabetic heart, we delivered adenovirus expressing
O-GlcNAcase (Adv-GCA) into the myocardium of STZ-induced diabetic mice. Our ... Cited by 43 - Related articles - All 6 versions
- ►endojournals.org DC Albarado, J McClaine, JM Stephens, RL … - Endocrinology, 2004 - Endocrine Soc A reduction in metabolic rate and fatty acid (FA) oxidation, perhaps associated
with low sympathetic nervous activity, are thought to increase the risk of
developing obesity and associated pathologies such as diabetes and ... Cited by 27 - Related articles - BL Direct - All 7 versions
- ►endojournals.org SM Clee, AD Attie - Endocrine reviews, 2007 - Endocrine Soc Inbred mouse strains provide genetic diversity comparable to that of the human
population. Like humans, mice have a wide range of diabetes-related phenotypes.
The inbred mouse strains differ in the response of their critical ... Cited by 29 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org EH Leiter, PC Reifsnyder - Diabetes, 2004 - Am Diabetes Assoc The genetic basis for the more common forms of human obesity predisposing to
insulin resistance and development of type 2 diabetes is multigenic rather than
monogenic in origin. New mouse “diabesity” models have been created by ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►physiology.org SA Shore - Journal of applied physiology, 2007 - Am Physiological Soc Epidemiological data indicate that obesity is a risk factor for asthma. These
data are supported by observations in several murine models of obesity. Ob/ob,
db/db, and Cpe fat mice each exhibit innate airway hyperresponsiveness, a ... Cited by 23 - Related articles - BL Direct - All 8 versions
- ►physiology.org J Kaput, KG Klein, EJ Reyes, WA Kibbe, CA … - Physiological Genomics, 2004 - Am Physiological Soc The incidence and severity of obesity and type 2 diabetes are increasing in
Western societies. The progression of obesity to type 2 diabetes is gradual with
overlapping symptoms of insulin resistance, hyperinsulinemia, ... Cited by 23 - Related articles - BL Direct - All 2 versions
