- ►daegu.ac.kr [PDF] R Sladek, G Rocheleau, J Rung, C Dina, L … - Nature, 2007 - nature.com Type 2 diabetes mellitus results from the interaction of environmental factors
with a combination of genetic variants, most of which were hitherto unknown. A
systematic search for these variants was recently made possible by the ... Cited by 770 - Related articles - BL Direct - All 14 versions
Q Yang, TE Graham, N Mody, F Preitner, OD … - Nature, 2005 - biotech.korea.ac.kr In obesity and type 2 diabetes, expression of the GLUT4 glucose transporter is
decreased selectively in adipocytes. Adipose-specific Glut4 (also known as
Slc2a4) knockout (adipose-Glut4 2 /2 ) mice show insulin resistance ... Cited by 579 - Related articles - View as HTML - All 13 versions
- ►nih.gov W Farris, S Mansourian, Y Chang, L Lindsley … - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences Two substrates of insulin-degrading enzyme (IDE), amyloid β-protein (Aβ) and
insulin, are critically important in the pathogenesis of Alzheimer's disease
(AD) and type 2 diabetes mellitus (DM2), respectively. We previously ... Cited by 373 - Related articles - BL Direct - All 6 versions
- ►shouxi.net TE Graham, Q Yang, M Bluher, A Hammarstedt … - The New England journal of medicine, 2006 - nejm.highwire.org Background Insulin resistance has a causal role in type 2 diabetes. Serum levels
of retinol-binding protein 4 (RBP4), a protein secreted by adipocytes, are
increased in insulin-resistant states. Experiments in mice suggest that ... Cited by 364 - Related articles - BL Direct - All 8 versions
CS Fox, JM Massaro, U Hoffmann, KM Pou, P … - Circulation, 2007 - Am Heart Assoc From the National Heart, Lung and Blood Institute's Framingham Heart Study (CSF,
CJO), Framingham, Mass; Division of Endocrinology, Metabolism, and Diabetes,
Department of Medicine (CSF, KMP), Brigham and Women's Hospital and Harvard ... Cited by 110 - Related articles - All 7 versions
I Barroso - Diabetic medicine, 2005 - interscience.wiley.com Type 2 diabetes (T2D) has become a health-care problem worldwide, with the rise
in disease prevalence being all the more worrying as it not only affects the
developed world but also developing nations with fewer resources to cope ... Cited by 101 - Related articles - All 6 versions
- ►oxfordjournals.org MI McCarthy - Human Molecular Genetics, 2004 - Oxford Univ Press The rapid increase in the prevalence of type 2 diabetes (T2D) represents a major
challenge for health care delivery worldwide. Identification of genes
influencing individual susceptibility to disease offers a route to better ... Cited by 94 - Related articles - All 4 versions
- ►amjpathol.org W Farris, S Mansourian, MA Leissring, EA … - American Journal of Pathology, 2004 - ASIP The causes of cerebral accumulation of amyloid ß-protein (Aß) in most cases of
Alzheimer's disease (AD) remain unknown. We recently found that homozygous
deletion of the insulin-degrading enzyme (IDE) gene in mice results in an ... Cited by 97 - Related articles - BL Direct - All 7 versions
MI McCarthy - Current diabetes reports, 2003 - Springer Introduction Type 2 diabetes (T2D), together with related traits such as obesity
and the other components of the metabolic syn- drome, has emerged as a dominant
cause of morbidity and mortality in societies across the globe [1]. Success ... Cited by 87 - Related articles - BL Direct - All 3 versions
- ►oxfordjournals.org F Demenais, T Kanninen, CM Lindgren, S … - Human Molecular Genetics, 2003 - Oxford Univ Press Positional cloning is expected to identify novel susceptibility genes underlying
complex traits, but replication of genome-wide linkage scan findings has proven
erratic. To improve our ability to detect and prioritize chromosomal ... Cited by 65 - Related articles - BL Direct - All 6 versions
