M Cnop, PJ Havel, KM Utzschneider, DB Carr, MK … - Diabetologia, 2003 - Springer Aims/hypothesis. Increased intra-abdominal fat is as- sociated with insulin resistance and an
atherogenic li- poprotein profile. Circulating concentrations of adip- onectin, an adipocyte-derived
protein, are decreased with insulin resistance. We investigated the relation- ships ... Cited by 528 - Related articles - BL Direct - All 5 versions
SE Kahn - Diabetologia, 2003 - Springer The relative contributions of insulin resistance and be- ta-cell dysfunction to the pathophysiology
of Type 2 diabetes have been debated extensively. The concept that a feedback loop governs
the interaction of the in- sulin-sensitive tissues and the beta cell as well as the elucidation ... Cited by 517 - Related articles - BL Direct - All 6 versions
DB Carr, KM Utzschneider, RL Hull, K Kodama, BM … - Diabetes, 2004 - Am Diabetes Assoc The underlying pathophysiology of the metabolic syndrome is the subject of debate, with both
insulin resistance and obesity considered as important factors. We evaluated the differential
effects of insulin resistance and central body fat distribution in determining the metabolic ... Cited by 348 - Related articles - BL Direct - All 5 versions
PJ Havel - Diabetes, 2004 - Am Diabetes Assoc Hormones produced by adipose tissue play a critical role in the regulation of energy intake, energy
expenditure, and lipid and carbohydrate metabolism. This review will address the biology,
actions, and regulation of three adipocyte hormones—leptin, acylation stimulating protein ... Cited by 341 - Related articles - BL Direct - All 7 versions
SE Kahn, RL Hull, KM Utzschneider - NATURE-LONDON-, 2006 - tesumassd.org The increased prevalence of obesity has focused attention on a world- wide problem that is not
one of famine or infection, but one of surplus. In the United States, only about a third of adults
are considered to be of 'normal' weight1, and similar trends are being observed ... Cited by 294 - Related articles - View as HTML - BL Direct - All 9 versions
- ►eje-online.org [PDF] JV Silha, M Krsek, JV Skrha, P Sucharda, BL Nyomba … - European Journal of …, 2003 - EFES Josef V Silha 1 , Michal Krsek 2 , Jan V Skrha 2 , Petr Sucharda 2 , BLG Nyomba 3 and Liam
J Murphy 1,3 ... Departments of 1 Physiology and 3 Internal Medicine, University of
Manitoba, Winnipeg, Canada and ... First Faculty of Medicine, Charles University, ... Cited by 255 - Related articles - BL Direct - All 8 versions
- ►cell.com P Arner - Trends in Endocrinology & Metabolism, 2003 - Elsevier Globally, the prevalence of obesity is escalating, and insulin resistance resulting from increased
(predominantly visceral) adipose tissue mass has been identified as a key factor that could drive
parallel rises in type 2 diabetes mellitus (T2DM) prevalence. Correlations between these ... Cited by 234 - Related articles - All 11 versions
RF Grimble - Current Opinion in Clinical Nutrition & Metabolic Care, 2002 - journals.lww.com Recent findings: Population studies show a strong association between indices of
inflammation, and abnormal lipid and carbohydrate metabolism, obesity and
atherosclerosis. TNF-α is produced, by cells of the immune system and by adipocytes. It ... Cited by 218 - Related articles - BL Direct - All 7 versions
- ►cnfindpark.cn GM Reaven - American Journal of Clinical Nutrition, 2006 - ajcn.cnfindpark.cn Values of insulin-mediated glucose disposal vary continuously throughout a population of apparently
healthy persons, and a difference of 600% exists between the most insulin-sensitive and the
most insulin-resistant persons. Approximately 50% of this variability can be attributed to ... Cited by 207 - Related articles - BL Direct - All 9 versions
- ►endojournals.org A Gavrila, JL Chan, N Yiannakouris, M … - Journal of Clinical …, 2003 - Endocrine Soc Adiponectin is an adipocyte-secreted protein that circulates in high concentrations in the serum
and acts to increase insulin sensitivity. Previous studies have shown that serum adiponectin
is inversely associated with fat mass and insulin resistance in humans and that acute ... Cited by 172 - Related articles - BL Direct - All 5 versions
