- ►endojournals.org MI Goran, GDC Ball, ML Cruz - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc Overweight/obesity continues to increase in children and adolescents, and annual
obesity-related hospital costs in 6–17 yr olds have reached $127 million per
year. Overweight children and adolescents are now being diagnosed with ... Cited by 304 - Related articles - BL Direct - All 5 versions
R Weiss, S Dufour, SE Taksali, WV Tamborlane … - The Lancet, 2003 - Elsevier Peripheral glucose disposal was significantly lower in individuals with impaired
than in those with normal glucose tolerance (mean 35·4 [SE 4·0] vs 60·6
[7·2] moles per kg lean body mass per min; p=0·023) owing to a reduction ... Cited by 190 - Related articles - All 6 versions
- ►jbc.org JA Chavez, TA Knotts, LP Wang, G Li, RT … - Journal of Biological Chemistry, 2003 - ASBMB Multiple studies suggest that lipid oversupply to skeletal muscle contributes to
the development of insulin resistance, perhaps by promoting the accumulation of
lipid metabolites capable of inhibiting signal transduction. Herein we ... Cited by 156 - Related articles - BL Direct - All 5 versions
- ►liptapro.net [PDF] RH Unger - Trends in Endocrinology & Metabolism, 2003 - Elsevier Approximately two-thirds of the US population are overweight, which means that
insulin resistance is probably the most common metabolic abnormality in the USA.
I propose three novel concepts concerning the causes and consequences of ... Cited by 158 - Related articles - All 14 versions
- ►physiology.org MV Chakravarthy, FW Booth - Journal of Applied Physiology, 2004 - Am Physiological Soc Survival of Homo sapiens during evolution was dependent on the procurement of
food, which in turn was dependent on physical activity. However, food supply was
never consistent. Thus it is contended that the ancient hunter-gatherer had ... Cited by 122 - Related articles - BL Direct - All 8 versions
SA Summers - Progress in Lipid Research, 2006 - Elsevier Obesity predisposes individuals to the development of insulin resistance in
skeletal muscle and the liver, and researchers have recently proposed two
mechanisms by which excess adiposity antagonizes insulin action in ... Cited by 114 - Related articles - All 3 versions
- ►endojournals.org R Weiss, S Dufour, A Groszmann, K Petersen, … - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc THE DISCOVERY OF leptin in 1994 has dramatically changed the view of adipose
tissue in the regulation of energy balance (1). This tissue secretes several
proteins that act as potential regulators of glucose and lipid homeostasis ... Cited by 112 - Related articles - BL Direct - All 5 versions
- ►endojournals.org CW Yeckel, R Weiss, J Dziura, SE Taksali, S … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Given the extreme increase in prediabetes, type 2 diabetes, and the potential
for metabolic syndrome in obese youth, identifying simplified indexes for
assessing stimulated insulin sensitivity is critical. The purpose of this ... Cited by 106 - Related articles - BL Direct - All 8 versions
S Klein, DB Allison, SB Heymsfield, DE … - American Journal of Clinical Nutrition, 2007 - Am Soc Nutrition Obesity is an important risk factor for cardiometabolic diseases, including
diabetes, hypertension, dyslipidemia, and coronary heart disease (CHD). Several
leading national and international institutions, including the World Health ... Cited by 96 - Related articles - BL Direct - All 15 versions
- ►biosino.org [PDF] - Free from Publisher ZT Bloomgarden - Diabetes care, 2004 - Am Diabetes Assoc We are in the midst of an epidemic of lack of exercise, of obesity, of the
insulin resistance syndrome (IRS), and of diabetes in young persons. The
diabetogenic process begins in fetal life, with low birth weight and poor ... Cited by 90 - Related articles - All 6 versions
