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Scholar Results 1 - 10 of about 85 citing Sewter: Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform.... (0.10 sec) 

SREBP transcription factors: master regulators of lipid homeostasis


D Eberle, B Hegarty, P Bossard, P Ferre, F … - Biochimie, 2004 - Elsevier
Sterol regulatory element binding proteins (SREBPs) are a family of
transcription factors that regulate lipid homeostasis by controlling the
expression of a range of enzymes required for endogenous cholesterol, fatty ...
Cited by 185 - Related articles - All 3 versions

Nuclear lamins: laminopathies and their role in premature ageing

- physiology.org
JLV Broers, FCS Ramaekers, G Bonne, RB … - Physiological reviews, 2006 - Am Physiological Soc
It has been demonstrated that nuclear lamins are important proteins in
maintaining cellular as well as nuclear integrity, and in maintaining chromatin
organization in the nucleus. Moreover, there is growing evidence that ...
Cited by 131 - Related articles - BL Direct - All 7 versions

Fructose, insulin resistance, and metabolic dyslipidemia


H Basciano, L Federico, K Adeli - Nutrition & Metabolism, 2005 - biomedcentral.com
Obesity and type 2 diabetes are occurring at epidemic rates in the United States
and many parts of the world. The "obesity epidemic" appears to have emerged
largely from changes in our diet and reduced physical activity. An ...
Cited by 123 - Related articles - Cached - All 13 versions

Isomer-dependent metabolic effects of conjugated linoleic acid


HM Roche, E Noone, C Sewter, S Mc Bennett, D … - Diabetes, 2002 - Am Diabetes Assoc
Conjugated linoleic acid (CLA) is a heterogeneous group of positional and
geometric isomers of linoleic acid. This study demonstrates the divergent
effects of the cis-9 trans-11 (c9,t11-CLA) and trans-10 cis-12 ...
Cited by 102 - Related articles - BL Direct - All 5 versions

Gene expression profiles of nondiabetic and diabetic obese mice suggest a role of hepatic …


H Lan, ME Rabaglia, JP Stoehr, ST Nadler, KL … - Diabetes, 2003 - Am Diabetes Assoc
Obesity is a strong risk factor for the development of type 2 diabetes. We have
previously reported that in adipose tissue of obese (ob/ob) mice, the expression
of adipogenic genes is decreased. When made genetically obese, the BTBR ...
Cited by 77 - Related articles - BL Direct - All 15 versions

Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and …

- jlr.org
MF Gregor, GS Hotamisligil - The Journal of Lipid Research, 2007 - ASBMB
In the context of obesity and its related maladies, the adipocyte plays a
central role in the balance, or imbalance, of metabolic homeostasis. An obese,
hypertrophic adipocyte is challenged by many insults, including surplus ...
Cited by 78 - Related articles - All 5 versions

Adipocyte determination-and differentiation-dependent factor 1/sterol regulatory element- …

- jbc.org
JB Seo, HM Moon, MJ Noh, YS Lee, HW Jeong, … - Journal of Biological Chemistry, 2004 - ASBMB
Adiponectin is exclusively expressed in differentiated adipocytes and plays an
important role in regulating energy homeostasis, including the glucose and lipid
metabolism associated with increased insulin sensitivity. However, the ...
Cited by 64 - Related articles - BL Direct - All 5 versions

Lipid and lipoprotein dysregulation in insulin resistant states


RK Avramoglu, H Basciano, K Adeli - Clinica chimica acta, 2006 - Elsevier
Insulin resistant states are commonly associated with an atherogenic
dyslipidemia that contributes to significantly higher risk of atherosclerosis
and cardiovascular disease. Indeed, disorders of carbohydrate and lipid ...
Cited by 58 - Related articles - All 3 versions

SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French …

- diabetesjournals.org
D Eberlé, K Clément, D Meyre, M Sahbatou, M … - Diabetes, 2004 - Am Diabetes Assoc
Sterol regulatory element–binding protein (SREBP)-1 transcription factors play
a central role in energy homeostasis by promoting glycolysis, lipogenesis, and
adipogenesis. The sterol regulatory element–binding protein gene ...
Cited by 53 - Related articles - BL Direct - All 4 versions

Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation


C Lelliott, AJ Vidal-Puig - International Journal of Obesity, 2004 - nature.com
Obesity and type 2 diabetes mellitus are the major noncommunicable public health
problem of the 21st century. The best strategy to tackle this problem is to
develop strategies to prevent/treat obesity. However, it is becoming clear ...
Cited by 47 - Related articles - All 4 versions


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