KD Niswender, MW Schwartz - Frontiers in neuroendocrinology, 2003 - Elsevier The adipocyte-derived hormone leptin and the pancreatic β cell-derived hormone
insulin each function as afferent signals to the hypothalamus in an endocrine
feedback loop that regulates body adiposity. Although these two hormones, ... Cited by 218 - Related articles - BL Direct - All 4 versions
C De Alvaro, T Teruel, R Hernandez, M … - Journal of Biological Chemistry, 2004 - ASBMB Insulin stimulation produced a reliable 3-fold increase in glucose uptake in
primary neonatal rat myotubes, which was accompanied by a similar effect on
GLUT4 translocation to plasma membrane. Tumor necrosis factor (TNF)-α ... Cited by 142 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org K Bouzakri, M Roques, P Gual, S Espinosa, F … - Diabetes, 2003 - Am Diabetes Assoc To understand better the defects in the proximal steps of insulin signaling
during type 2 diabetes, we used differentiated human skeletal muscle cells in
primary culture. When compared with cells from control subjects, myotubes ... Cited by 98 - Related articles - BL Direct - All 4 versions
M Beeson, MP Sajan, M Dizon, D Grebenev, J … - Diabetes, 2003 - Am Diabetes Assoc Insulin resistance in type 2 diabetes is partly due to impaired glucose
transport in skeletal muscle. Atypical protein kinase C (aPKC) and protein
kinase B (PKB), operating downstream of phosphatidylinositol (PI) 3-kinase ... Cited by 90 - Related articles - BL Direct - All 4 versions
YB Kim, K Kotani, TP Ciaraldi, RR Henry, BB … - Diabetes, 2003 - Am Diabetes Assoc In humans with obesity or type 2 diabetes, insulin target tissues are resistant
to many actions of insulin. The atypical protein kinase C (PKC) isoforms λ and
ζ are downstream of phosphatidylinositol-3 kinase (PI3K) and are required ... Cited by 79 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org GK Bandyopadhyay, JG Yu, J Ofrecio, JM … - Diabetes, 2005 - Am Diabetes Assoc Insulin resistance is predominantly characterized by decreased
insulin-stimulated glucose uptake into skeletal muscle. In the current study, we
have assessed various aspects of the phosphatidylinositol (PI) 3-kinase ... Cited by 80 - Related articles - BL Direct - All 5 versions
- ►physiology.org DS Fernandez-Twinn, A Wayman, S Ekizoglou … - … Journal of Physiology- Regulatory, Integrative and …, 2005 - Am Physiological Soc Human adult diseases such as cardiovascular disease, hypertension, and type 2
diabetes have been epidemiologically linked to poor fetal growth and
development. Male offspring of rat dams fed a low-protein (LP) diet during ... Cited by 66 - Related articles - All 4 versions
YB Kim, GI Shulman, BB Kahn - Journal of Biological Chemistry, 2002 - ASBMB To determine the mechanism(s) for insulin resistance induced by fatty acids, we
measured the ability of insulin to activate phosphoinositide 3-kinase (PI3K) and
multiple distal pathways in rats. Following a 5-h infusion of lipid or ... Cited by 62 - Related articles - BL Direct - All 6 versions
- ►physiology.org A Corbould, YB Kim, JF Youngren, C Pender, … - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc Insulin resistance in polycystic ovary syndrome (PCOS) is due to a postbinding
defect in signaling that persists in cultured skin fibroblasts and is associated
with constitutive serine phosphorylation of the insulin receptor (IR). ... Cited by 62 - Related articles - All 3 versions
