- ►physiology.org IC Mcmillen, JS Robinson - Physiological reviews, 2005 - Am Physiological Soc The "fetal" or "early" origins of adult disease hypothesis was originally put
forward by David Barker and colleagues and stated that environmental factors,
particularly nutrition, act in early life to program the risks for adverse ... Cited by 439 - Related articles - All 11 versions
- ►diabetesjournals.org [PDF] ES Ford - Diabetes Care, 2005 - Am Diabetes Assoc OBJECTIVE — In recent years, several major organizations have endorsed the
concept of the metabolic syndrome and developed working definitions for it. How
well these definitions predict the risk for adverse events in people with ... Cited by 439 - Related articles - BL Direct - All 6 versions
- ►endojournals.org JW Tomlinson, EA Walker, IJ Bujalska, N … - Endocrine Reviews, 2004 - Endocrine Soc 11ß-Hydroxysteroid dehydrogenase type 1 (11ß-HSD1) interconverts inactive
cortisone and active cortisol. Although bidirectional, in vivo it is believed to
function as a reductase generating active glucocorticoid at a prereceptor ... Cited by 253 - Related articles - BL Direct - All 4 versions
- ►nih.gov H Masuzaki, H Yamamoto, CJ Kenyon, JK … - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig Obesity is closely associated with the metabolic syndrome, a combination of
disorders including insulin resistance, diabetes, dyslipidemia, and
hypertension. A role for local glucocorticoid reamplification in obesity ... Cited by 218 - Related articles - BL Direct - All 6 versions
JR Seckl - European Journal of Endocrinology, 2004 - EFES Epidemiological evidence suggests that low birth weight is associated with an
increased risk of cardio- vascular, metabolic and neuroendocrine disorders in
adult life. Glucocorticoid administration during pregnancy reduces ... Cited by 196 - Related articles - BL Direct - All 12 versions
JR Seckl, MJ Meaney - Ann NY Acad Sci, 2004 - earlylearning.ubc.ca ABSTRACT: Epidemiological evidence suggests that an adverse fetal environ- ment
permanently programs physiology, leading to increased risks of cardio- vascular,
metabolic, and neuroendocrine disorders in adulthood. Prenatal ... Cited by 161 - Related articles - View as HTML - All 7 versions
- ►endojournals.org DJ Wake, E Rask, DEW Livingstone, S … - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc 11ß-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11HSD1) is a potential target for
pharmacological inhibition in obesity and the metabolic syndrome. It catalyzes
the conversion of inactive cortisone to active cortisol, thereby amplifying ... Cited by 139 - Related articles - All 6 versions
- ►rupress.org A Hermanowski-Vosatka, JM Balkovec, K Cheng … - Journal of Experimental Medicine, 2005 - jem.rupress.org The enzyme 11ß–hydroxysteroid dehydrogenase (HSD) type 1 converts inactive
cortisone into active cortisol in cells, thereby raising the effective
glucocorticoid (GC) tone above serum levels. We report that pharmacologic ... Cited by 121 - Related articles - BL Direct - All 8 versions
JR Seckl, NM Morton, KE Chapman, BR … - Recent progress in hormone research, 2004 - Endocrine Soc The highly prevalent metabolic syndrome (insulin resistance, type 2 diabetes,
dyslipidemia, hypertension, along with abdominal obesity) resembles Cushing's
syndrome. However, in simple obesity, plasma cortisol levels are not ... Cited by 99 - Related articles - BL Direct - All 2 versions
- ►endojournals.org RC Andrews, O Herlihy, DEW Livingstone, R … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc In summary, in patients with glucose intolerance, cortisol secretion, although
normal, is inappropriately high given enhanced central and peripheral
sensitivity to glucocorticoids. Normal 11ß-HSD 1 activity in adipose ... Cited by 97 - Related articles - BL Direct - All 5 versions
