- ►pnas.org ME Patti, AJ Butte, S Crunkhorn, K Cusi, … - Proceedings of the …, 2003 - National Acad Sciences Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic β cell
dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal
muscle. Impaired insulin-mediated signaling, gene expression, glycogen synthesis, and ... Cited by 667 - Related articles - BL Direct - All 15 versions
E Bonora, S Kiechl, J Willeit, F Oberhollenzer, G … - International Journal of …, 2003 - nature.com RESULTS: The prevalence of the Metabolic Syndrome by WHO criteria was 34.1% (95% CI
31.0–37.2) and by NCEP-ATPIII criteria 17.8% (15.5–20.3). The prevalence was significantly
higher in older subjects and in those less physically active. Subjects with the Metabolic ... Cited by 138 - Related articles - BL Direct - All 3 versions
CR Bruce, AL Carey, JA Hawley, MA Febbraio - Diabetes, 2003 - Am Diabetes Assoc To examine whether genes associated with cellular defense against oxidative stress are associated
with insulin sensitivity, patients with type 2 diabetes (n = 7) and age-matched (n = 5) and young
(n = 9) control subjects underwent a euglycemic-hyperinsulinemic clamp for 120 min. ... Cited by 87 - Related articles - BL Direct - All 4 versions
- ►physiology.org M Atalay, NKJ Oksala, DE Laaksonen, S … - Journal of Applied …, 2004 - Am Physiological Soc Strenuous exercise induces oxidative stress and modification of intracellular proteins. Exercise
training, however, upregulates endogenous antioxidant defenses and heat shock protein
(HSP) expression. In diabetes, perturbations in the endogenous antioxidant and HSP ... Cited by 58 - Related articles - BL Direct - All 7 versions
JP DeLany, ZE Floyd, S Zvonic, A Smith, A Gravois, … - Molecular and Cellular …, 2005 - ASBMB Title: Proteomic Analysis of Primary Cultures of Human Adipose Derived Stem Cells: Modulation
by Adipogenesis ... Authors: James Delany1,2 Z. Elizabeth Floyd3 Sanjin Zvonic3 Andrea
Smith2,4 Amy Gravois1,2 Eric Reiners1,2 Xiying Wu3 Gail Kilroy3 Michael Lefevre2,4 ... Cited by 48 - Related articles - BL Direct - All 6 versions
- ►nih.gov J Chung, AK Nguyen, DC Henstridge, AG … - Proceedings of the …, 2008 - National Acad Sciences Patients with type 2 diabetes have reduced gene expression of heat shock protein (HSP) 72,
which correlates with reduced insulin sensitivity. Heat therapy, which activates HSP72, improves
clinical parameters in these patients. Activation of several inflammatory signaling proteins ... Cited by 30 - Related articles - BL Direct - All 8 versions
Y Liu, L Gampert, K Nething, JM Steinacker - Front Biosci, 2006 - bioscience.org 1. Abstract 2. Introduction 3. Biology of Hsp70 3.1. General features and structure of Hsp70
3.1.1. General features of Hsp70 3.1.2. Molecular structure of Hsp70 3.2. Induction of Hsp70
3.3. Regulation of Hsp70 response/expression 3.4. Basic functions of Hsp70 3.4.1. ... Cited by 27 - Related articles - View as HTML - All 2 versions
- ►physiology.org CP Fischer, NJ Hiscock, S Basu, B Vessby … - Journal of Applied …, 2006 - Am Physiological Soc Increased levels of reactive oxygen and nitrogen species, as seen in response to exercise, challenge
the cellular integrity. Important protective adaptive changes include induction of heat shock proteins
(HSPs). We hypothesized that supplementation with antioxidant vitamins C (ascorbic ... Cited by 23 - Related articles - BL Direct - All 7 versions
MF McCarty - Medical hypotheses, 2006 - Elsevier The molecular mechanism responsible for obesity-associated insulin resistance has been partially
clarified: increased fatty acid levels in muscle fibers promote diacylglycerol synthesis, which
activates certain isoforms of protein kinase C (PKC). This in turn triggers a kinase ... Cited by 17 - Related articles - All 32 versions
- ►hspsanddiabetes.com [PDF] PL Hooper, JJ Hooper - Diabetes Technology & Therapeutics, 2005 - liebertonline.com W E PROPOSE THAT DIABETES produces a vul- nerable condition with impaired de- fenses
against stress, resulting in widespread unprotected organ systems. More specifi- cally, the ultimate
natural history of diabetes and its complications is determined by the net effect of ... Cited by 16 - Related articles - All 4 versions
