- ►endojournals.org JL Evans, ID Goldfine, BA Maddux, GM … - Endocrine Reviews, 2002 - Endocrine Soc In both type 1 and type 2 diabetes, the late diabetic complications in nerve,
vascular endothelium, and kidney arise from chronic elevations of glucose and
possibly other metabolites including free fatty acids (FFA). Recent ... Cited by 593 - Related articles - BL Direct - All 18 versions
- ►asnjournals.org RM Mason, NA Wahab - Journal of the American Society of Nephrology, 2003 - Am Soc Nephrol Diabetes mellitus has recently assumed epidemic proportions, partly due to the 2
to 5% increase in the incidence of type 1 diabetes in children, but especially
due to the global increase in type 2 diabetes (1). Currently as many as 4% ... Cited by 159 - Related articles - BL Direct - All 9 versions
- ►uc.pt [PDF] AP Rolo, CM Palmeira - Toxicology and applied pharmacology, 2006 - Elsevier Hyperglycemia resulting from uncontrolled glucose regulation is widely
recognized as the causal link between diabetes and diabetic complications. Four
major molecular mechanisms have been implicated in hyperglycemia-induced ... Cited by 119 - Related articles - All 7 versions
NE Zachara, GW Hart - BBA-General Subjects, 2004 - Elsevier Myriad nuclear and cytoplasmic proteins in metazoans are modified on Ser and Thr
residues by the monosaccharide O-linked β-N-acetylglucosamine (O-GlcNAc). The
rapid and dynamic change in O-GlcNAc levels in response to extracellular ... Cited by 107 - Related articles - All 5 versions
GR Dodge, SA Jimenez - Osteoarthritis and Cartilage, 2003 - Elsevier Objective: The functional integrity of articular cartilage is determined by a
balance between chondrocyte biosynthesis of extracellular matrix and its
degradation. In osteoarthritis (OA), the balance is disturbed by an ... Cited by 90 - Related articles - All 7 versions
L Wells, SA Whelan, GW Hart - Biochemical and Biophysical Research …, 2003 - Elsevier In 1984, Torres and Hart described the presence of O-glycosidically linked
GlcNAc monosaccharides on cell-surface proteins and suggested that the majority
of O-GlcNAc modified proteins appeared to be within the cell [1]. A couple ... Cited by 89 - Related articles - BL Direct - All 5 versions
- ►jbc.org GJ Parker, KC Lund, RP Taylor, DA McClain - Journal of Biological Chemistry, 2003 - ASBMB We have investigated the mechanism by which high concentrations of glucose
inhibit insulin stimulation of glycogen synthase. In NIH-3T3-L1 adipocytes
cultured in low glucose (LG; 2.5 mM), the half-maximal activation ... Cited by 86 - Related articles - BL Direct - All 5 versions
NE Zachara, GW Hart - BBA-Molecular and Cell Biology of Lipids, 2006 - Elsevier An increasing body of evidence points to a central regulatory role for glucose
in mediating cellular processes and expands the role of glucose well beyond its
traditional role(s) in energy metabolism. Recently, it has been recognized ... Cited by 78 - Related articles - All 4 versions
- ►ahajournals.org SA Whelan, GW Hart - Circulation research, 2003 - Am Heart Assoc O-linked ß-N-acetylglucosamine (O-GlcNAc) is both an abundant and dynamic
posttranslational modification similar to phosphorylation that occurs on serine
and threonine residues of cytosolic and nuclear proteins in all metazoans ... Cited by 69 - Related articles - BL Direct - All 7 versions
K Vosseller, K Sakabe, L Wells, GW Hart - Current opinion in chemical biology, 2002 - Elsevier N-Acetylglucosamine O-linked to serines and threonines of cytosolic and nuclear
proteins (O-GlcNAc) is an abundant reversible post-translational modification
found in all higher eukaryotes. Evidence for functional regulation of ... Cited by 69 - Related articles - All 4 versions
