- ►endojournals.org ZY Fang, JB Prins, TH Marwick - Endocrine reviews, 2004 - Endocrine Soc The existence of a diabetic cardiomyopathy is supported by epidemiological
findings showing the association of diabetes with heart failure; clinical
studies confirming the association of diabetes with left ventricular ... Cited by 232 - Related articles - BL Direct - All 8 versions
S Boudina, ED Abel - Circulation, 2007 - Am Heart Assoc The prevalence of diabetes mellitus is growing rapidly. It is estimated that
globally the number of adults affected with diabetes will increase from 135
million in 1995 to 300 million by 2025. 1 Patients with diabetes mellitus ... Cited by 136 - Related articles - All 5 versions
- ►nih.gov M Yano, Y Ikeda, M Matsuzaki - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Heart failure (HF) is characterized by a complex disorder that leads to a
disturbance of the normal pumping of blood to the peripheral organs to meet the
metabolic demands of the body. In a heart that has suffered myocardial ... Cited by 104 - Related articles - All 8 versions
RJ Clark, PM McDonough, E Swanson, SU … - Journal of Biological Chemistry, 2003 - ASBMB Diabetic cardiomyopathy is characterized by impaired cardiac contractility
leading to poor myocardial performance. We investigated the role that the
hexosamine pathway, and especially altered nuclear O-Glc-NAcylation, plays ... Cited by 98 - Related articles - BL Direct - All 4 versions
- ►physiology.org KM Choi, Y Zhong, BD Hoit, IL Grupp, H Hahn, … - American Journal of Physiology- Heart and Circulatory …, 2002 - Am Physiological Soc The goal of the study was to determine whether defects in intracellular Ca 2+
signaling contribute to cardiomyopathy in streptozotocin (STZ)-induced diabetic
rats. Depression in cardiac systolic and diastolic function was traced from ... Cited by 86 - Related articles - BL Direct - All 9 versions
D An, B Rodrigues - American Journal of Physiology- Heart and Circulatory …, 2006 - Am Physiological Soc In patients with diabetes, an increased risk of symptomatic heart failure
usually develops in the presence of hypertension or ischemic heart disease.
However, a predisposition to heart failure might also reflect the effects ... Cited by 66 - Related articles - BL Direct - All 5 versions
KR Bidasee, Y Zhang, CH Shao, M Wang, KP … - Diabetes, 2004 - Am Diabetes Assoc Prolongation of relaxation is a hallmark of diabetic cardiomyopathy. Most
studies attribute this defect to decreases in sarco(endo)plasmic reticulum Ca 2+
-ATPase (SERCA2a) expression and SERCA2a-to-phospholamban (PLB) ratio. ... Cited by 58 - Related articles - BL Direct - All 4 versions
- ►ahajournals.org GW Dorn, JD Molkentin - Circulation, 2004 - Am Heart Assoc The cardiac ß-adrenergic signaling network is highly specialized in the
myocardium as a direct regulator of contractility through changes in intrinsic
inotropy and chronotropy (heart rate). Norepinephrine- and ... Cited by 53 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org DD Belke, EA Swanson, WH Dillmann - Diabetes, 2004 - Am Diabetes Assoc Although it is known that insulin-dependent (type 1) diabetes results in
depressed contractile performance associated with diminished sarcoendoplasmic
reticular Ca 2+ -ATPase (SERCA2a) activity, findings in insulin-resistant ... Cited by 53 - Related articles - BL Direct - All 6 versions
- ►physiology.org J Suarez, DD Belke, B Gloss, T Dieterle, PM … - American Journal of Physiology- Heart and Circulatory …, 2004 - Am Physiological Soc In many types of heart failure cardiac myocyte Ca 2+ handling is abnormal
because of downregulation of key Ca 2+ -handling proteins like
sarco(endo)plasmic reticulum Ca 2+ -ATPase (SERCA)2a and ryanodine receptor ... Cited by 45 - Related articles - BL Direct - All 4 versions
