- ►sciencesignaling.org [PDF] J Grimsby, R Sarabu, WL Corbett, NE Haynes, FT … - Science, 2003 - sciencemag.org Page 1. DOI: 10.1126/science.1084073 , 370 (2003); 301 Science et al. Joseph
Grimsby, in Diabetes Therapy Allosteric Activators of Glucokinase: Potential Role
www.sciencemag.org (this information is current as of January ... Cited by 187 - Related articles - All 12 versions
- ►diabetesjournals.org FM Matschinsky - Diabetes, 2002 - Am Diabetes Assoc Glucokinase (GK) serves as glucose sensor in pancreatic β-cells and in other glucose sensor
cells in the body. Biochemical genetic studies have characterized many activating and inactivating
GK mutants that have been discovered in patients with hyperinsulinemic hypoglycemia or ... Cited by 127 - Related articles - BL Direct - All 5 versions
AL Gloyn - Human mutation, 2003 - interscience.wiley.com Glucokinase is a key regulatory enzyme in the pancreatic beta-cell. It plays a crucial role in the
regulation of insulin secretion and has been termed the pancreatic beta-cell sensor. Given its
central role in the regulation of insulin release, it is understandable that mutations in the ... Cited by 121 - Related articles - BL Direct - All 6 versions
- ►physiology.org MJ Dunne, KE Cosgrove, RM Shepherd, A … - Physiological …, 2004 - Am Physiological Soc The earliest description of hyperinsulinism appears to have been that provided by Laidlaw in
1938 who used the term nesidioblastosis to describe the severe, recurrent hypoglycemia associated
with an inappropriate elevation of serum insulin, C-peptide, and proinsulin (161). While ... Cited by 108 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org AL Gloyn, K Noordam, MAAP Willemsen, S Ellard, … - Diabetes, 2003 - Am Diabetes Assoc Glucokinase (GCK) is a key regulatory enzyme in the pancreatic β-cell and catalyzes the
rate-limiting step for β-cell glucose metabolism. We report two novel GCK mutations (T65I and
W99R) that have arisen de novo in two families with familial hypoglycemia. Insulin levels, ... Cited by 78 - Related articles - BL Direct - All 5 versions
KJ Brocklehurst, VA Payne, RA Davies, D Carroll, HL … - Diabetes, 2004 - Am Diabetes Assoc Glucokinase (GK) has a major role in the control of blood glucose homeostasis and is a strong
potential target for the pharmacological treatment of type 2 diabetes. We report here the mechanism
of action of two novel and potent direct activators of GK: 6-[(3-isobutoxy-5- ... Cited by 76 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org FM Matschinsky, MA Magnuson, D Zelent, TL Jetton, N … - Diabetes, 2006 - Am Diabetes Assoc The glucose-phosphorylating enzyme glucokinase has structural, kinetic, and molecular genetic
features that are ideal for its primary role as glucose sensor in a network of neuro/endocrine
sentinel cells that maintain glucose homeostasis in many vertebrates including humans. ... Cited by 75 - Related articles - BL Direct - All 10 versions
A Molven, GE Matre, M Duran, RJ Wanders, U Rishaug … - Diabetes, 2004 - Am Diabetes Assoc Inappropriately elevated insulin secretion is the hallmark of persistent hyperinsulinemic hypoglycemia
of infancy (PHHI), also denoted congenital hyperinsulinism. Causal mutations have been uncovered
in genes coding for the β-cell's ATP-sensitive potassium channel and the metabolic ... Cited by 68 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org AL Cuesta-Muñoz, H Huopio, T Otonkoski, JM Gomez- … - Diabetes, 2004 - Am Diabetes Assoc Glucokinase (GK) is a glycolytic key enzyme that functions as a glucose sensor in the pancreatic
β-cell, where it governs glucose-stimulated insulin secretion (GSIS). Heterozygous inactivating
mutations in the glucokinase gene (GCK) cause a mild form of diabetes (maturity-onset ... Cited by 69 - Related articles - BL Direct - All 5 versions
- ►endojournals.org C Bouche, S Serdy, CR Kahn, AB Goldfine - Endocrine reviews, 2004 - Endocrine Soc Type 2 diabetes is a complex disorder with diminished insulin secretion and insulin action contributing
to the hyperglycemia and wide range of metabolic defects that underlie the disease. The contribution
of glucose metabolic pathways per se in the pathogenesis of the disease remains ... Cited by 53 - Related articles - BL Direct - All 6 versions
