- ►endojournals.org T Kadowaki, T Yamauchi - Endocrine Reviews, 2005 - Endocrine Soc Recently, we have cloned adiponectin receptors in the skeletal muscle (AdipoR1) and liver
(AdipoR2), which appear to comprise a novel cell-surface receptor family. We showed that AdipoR1
and AdipoR2 serve as receptors for globular and full-length adiponectin and mediate ... Cited by 634 - Related articles - All 8 versions
- ►nih.gov T Kadowaki, T Yamauchi, N Kubota, K … - Journal of Clinical …, 2006 - Am Soc Clin Investig Adiponectin is an adipokine that is specifically and abundantly expressed in adipose tissue and
directly sensitizes the body to insulin. Hypoadiponectinemia, caused by interactions of genetic
factors such as SNPs in the Adiponectin gene and environmental factors causing obesity, ... Cited by 411 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org M Chandran, SA Phillips, T Ciaraldi, RR Henry - Diabetes Care, 2003 - Am Diabetes Assoc Recent research has shown that adipose tissue is not simply an inert storage depot for lipids
but is also an important endocrine organ that plays a key role in the integration of endocrine,
metabolic, and inflammatory signals for the control of energy homeostasis. The adipocyte ... Cited by 393 - Related articles - BL Direct - All 5 versions
- ►oxfordjournals.org F Vasseur, N Helbecque, C Dina, S Lobbens, … - Human Molecular …, 2002 - Oxford Univ Press Adiponectin (ACRP30), an adipocyte-secreted protein encoded by the APM1 gene, is known
to modulate insulin sensitivity and glucose homeostasis, those effects protecting obese mice
from diabetes. Plasma adiponectin levels correlate well with insulin sensitivity in humans, ... Cited by 295 - Related articles - BL Direct - All 7 versions
K Silander, KL Mohlke, LJ Scott, EC Peck, P Hollstein, … - Diabetes, 2004 - Am Diabetes Assoc The Finland-United States Investigation Of NIDDM Genetics (FUSION) study aims to identify
genetic variants that predispose to type 2 diabetes by studying affected sibling pair families from
Finland. Chromosome 20 showed our strongest initial evidence for linkage. It currently ... Cited by 205 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org LD Love-Gregory, J Wasson, J Ma, CH Jin, B Glaser, … - Diabetes, 2004 - Am Diabetes Assoc Variants in hepatocyte nuclear factor-4α (HNF4α), a transcription factor that influences the expression
of glucose metabolic genes, have been correlated with maturity-onset diabetes of the young,
a monogenic form of diabetes. Previously, in a genome scan of Ashkenazi Jewish type 2 ... Cited by 169 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org K Hara, M Horikoshi, T Yamauchi, H Yago, O … - Diabetes Care, 2006 - Am Diabetes Assoc OBJECTIVE—The high–molecular weight (HMW) form of adiponectin, an adipocyte-derived
insulin-sensitizing hormone, has been reported to be the most active form of this hormone. We
investigated whether measurement of plasma HMW adiponectin levels, using our newly ... Cited by 147 - Related articles - BL Direct - All 5 versions
I Barroso - Diabetic medicine, 2005 - interscience.wiley.com Type 2 diabetes (T2D) has become a health-care problem worldwide, with the rise in disease
prevalence being all the more worrying as it not only affects the developed world but also developing
nations with fewer resources to cope with yet another major disease burden. Furthermore, ... Cited by 101 - Related articles - All 6 versions
MI McCarthy - Current diabetes reports, 2003 - Springer Introduction Type 2 diabetes (T2D), together with related traits such as obesity and the other
components of the metabolic syn- drome, has emerged as a dominant cause of morbidity and
mortality in societies across the globe [1]. Success in man- aging this “epidemic” of ... Cited by 87 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org MN Weedon, KR Owen, B Shields, G Hitman, M Walker … - Diabetes, 2004 - Am Diabetes Assoc Hepatocyte nuclear factor (HNF)-4α is part of a transcription factor network that is key for the
development and function of the β-cell. Rare mutations in the HNF4α gene cause maturity-onset
diabetes of the young. A number of type 2 diabetes linkage studies have found evidence ... Cited by 85 - Related articles - BL Direct - All 5 versions
