P Ferré - Diabetes, 2004 - Am Diabetes Assoc Peroxisome proliferator-activated receptors (PPARs) are transcription factors belonging to the
superfamily of nuclear receptors. Three isoforms (α, δ, and γ) have been described. They act
on DNA response elements as heterodimers with the nuclear retinoic acid receptor. Their ... Cited by 251 - Related articles - BL Direct - All 7 versions
DM Muoio, PS MacLean, DB Lang, S Li, JA … - Journal of Biological …, 2002 - ASBMB Ablation of peroxisome proliferator activated receptor (PPAR) α, a lipid-activated transcription
factor that regulates expression of β-oxidative genes, results in profound metabolic abnormalities
in liver and heart. In the present study we used PPARα knockout (KO) mice to determine ... Cited by 233 - Related articles - BL Direct - All 6 versions
- ►nih.gov Y Liu, J Binz, MJ Numerick, S Dennis, G … - Journal of Clinical …, 2003 - Am Soc Clin Investig Farnesoid X receptor (FXR) is a bile acid–activated transcription factor that is a member of the
nuclear hormone receptor superfamily. Fxr-null mice exhibit a phenotype similar to Byler
disease, an inherited cholestatic liver disorder. In the liver, activation of FXR induces ... Cited by 130 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org H Kim, M Haluzik, Z Asghar, D Yau, JW Joseph, AM … - Diabetes, 2003 - Am Diabetes Assoc Abnormalities in insulin action are the characteristics of type 2 diabetes. Dominant-negative
muscle-specific IGF-I receptor (MKR) mice exhibit elevated lipid levels at an early age and eventually
develop type 2 diabetes. To evaluate the role of elevated lipids in the progression of the ... Cited by 110 - Related articles - BL Direct - All 4 versions
EH Koh, MS Kim, JY Park, HS Kim, JY Youn, HS Park, … - Diabetes, 2003 - Am Diabetes Assoc Lipid accumulation in nonadipose tissues is closely related to the development of type 2 diabetes
in obese subjects. We examined the potential preventive effect of peroxisome proliferator-activated
receptor (PPAR)-α and PPAR-γ stimulation on the development of diabetes in obese ... Cited by 104 - Related articles - BL Direct - All 6 versions
- ►jbc.org TR Koves, P Li, J An, T Akimoto, D Slentz, O … - Journal of Biological …, 2005 - ASBMB Peroxisome proliferator-activated receptor- co-activator 1 (PGC1 ) is a promiscuous co-activator
that plays a key role in regulating mitochondrial biogenesis and fuel homeostasis. Emergent
evidence links decreased skeletal muscle PGC1 activity and coincident impairments in ... Cited by 104 - Related articles - BL Direct - All 4 versions
- ►cell.com MW Hulver, JR Berggren, MJ Carper, M Miyazaki, JM … - Cell Metabolism, 2005 - Elsevier Obesity and type 2 diabetes are strongly associated with abnormal lipid metabolism and accumulation
of intramyocellular triacylglycerol, but the underlying cause of these perturbations are yet
unknown. Herein, we show that the lipogenic gene, stearoyl-CoA desaturase 1 (SCD1), is ... Cited by 76 - Related articles - All 11 versions
AJ Gilde, M Van Bilsen - Acta Physiologica Scandinavica, 2003 - interscience.wiley.com The peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone
receptor superfamily. The three isoforms (PPARα, β/δ and γ) have been implicated in the regulation
of the expression of genes involved in lipid metabolism. Although their prominent role in ... Cited by 77 - Related articles - BL Direct - All 4 versions
F Forcheron, A Cachefo, S Thevenon, C Pinteur, M … - Diabetes, 2002 - Am Diabetes Assoc In humans, the precise mechanisms of the hypolipidemic action of fenofibrate, a peroxisome
proliferator-activated receptor-α agonist, remain unclear. To gain insight on these
mechanisms, we measured plasma lipids levels, lipids synthesis (hepatic de novo ... Cited by 74 - Related articles - BL Direct - All 5 versions
I Raz, R Eldor, S Cernea, E Shafrir - Diabetes/Metabolism Reviews - interscience.wiley.com We present multiple findings on derangements in lipid metabolism in type 2 diabetes. The increase
in the intracellular deposition of triglycerides (TG) in muscles, liver and pancreas in subjects
prone to diabetes is well documented and demonstrated to attenuate glucose metabolism ... Cited by 71 - Related articles - All 3 versions
