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Scholar Results 1 - 10 of about 76 citing Hruz: Indinavir induces acute and reversible peripheral insulin resistance in rats. (0.09 sec) 

Indinavir acutely inhibits insulin-stimulated glucose disposal in humans: a randomized, …


MA Noor, T Seneviratne, FT Aweeka, JC Lo, … - Aids, 2002 - journals.lww.com
From the From the Department of a Medicine, University of California, the b
Metabolism and Endocrine Sections, San Francisco Department of Veterans Affairs
Medical Center, the Department of c Pharmacology University of California, ...
Cited by 224 - Related articles - BL Direct - All 8 versions

The metabolic effects of lopinavir/ritonavir in HIV-negative men


GA Lee, T Seneviratne, MA Noor, JC Lo, JM … - Aids, 2004 - journals.lww.com
From the a Metabolism and Endocrine Sections, San Francisco Department of
Veterans Affairs Medical Center, San Francisco, CA, USA; b Department of
Medicine, University of California, San Francisco, CA, USA; c Division of ...
Cited by 130 - Related articles - BL Direct - All 6 versions

Effects of atazanavir/ritonavir and lopinavir/ritonavir on glucose uptake and insulin sensitivity …


MA Noor, OP Flint, JF Maa, RA Parker - Aids, 2006 - journals.lww.com
Methods: Glucose uptake was measured following insulin stimulation in
differentiated human adipocytes in the presence of ritonavir (2 μmol/l)
combined with either atazanavir or lopinavir (3-30 μmol/l). These data ...
Cited by 76 - Related articles - BL Direct - All 11 versions

Metabolic complications associated with HIV protease inhibitor therapy

- adisonline.com [PDF] 
D Nolan - Drugs, 2003 - ingentaconnect.com
HIV protease inhibitors were introduced into clinical practice over 7 years ago
Abstract as an important component of combination antiretroviral drug regimens
which in many ways revolutionised the treatment of HIV infection. The ...
Cited by 54 - Related articles - BL Direct - All 7 versions

Agent and cell-type specificity in the induction of insulin resistance by HIV protease …


R Ben-Romano, A Rudich, D Török, S … - Aids, 2003 - journals.lww.com
Objective: To test agent and cell-type specificity in insulin resistance induced
by prolonged exposure to HIV protease inhibitors (HPI), and to assess its
relation to the direct, short-term inhibition of insulin-stimulated glucose ...
Cited by 53 - Related articles - BL Direct - All 8 versions

HIV protease inhibitors acutely impair glucose-stimulated insulin release


JC Koster, MS Remedi, H Qiu, CG Nichols, … - Diabetes, 2003 - Am Diabetes Assoc
HIV protease inhibitors (PIs) acutely and reversibly inhibit the
insulin-responsive glucose transporter Glut 4, leading to peripheral insulin
resistance and impaired glucose tolerance. Minimal modeling analysis of ...
Cited by 54 - Related articles - BL Direct - All 5 versions

Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis


W Niu, C Huang, Z Nawaz, M Levy, R Somwar, D … - Journal of Biological Chemistry, 2003 - ASBMB
Insulin stimulates glucose uptake in skeletal muscle cells and fat cells by
promoting the rapid translocation of GLUT4 glucose transporters to the plasma
membrane. Recent work from our laboratory supports the concept that insulin ...
Cited by 48 - Related articles - BL Direct - All 5 versions

Indinavir impairs endothelial function in healthy HIV-negative men


SS Shankar, MP Dubé, JC Gorski, JE Klaunig … - American Heart Journal, 2005 - Elsevier
After 4 weeks of indinavir, the endothelium-dependent response to methacholine
chloride was impaired (195% ± 38% vs 83% ± 13%, P < .05), the response to N G
-mono-methyl-l-arginine (nitric oxide–dependent tone) was nearly ...
Cited by 39 - Related articles - All 28 versions

A Structural Basis for the Acute Effects of HIV Protease Inhibitors on GLUT 4 Intrinsic Activity


J Hertel, H Struthers, CB Horj, PW Hruz - Journal of Biological Chemistry, 2004 - ASBMB
Human immunodeficiency virus (HIV) protease inhibitors (PIs) act as reversible
noncompetitive inhibitors of GLUT4 with binding affinities in the low micromolar
range and are known to contribute to alterations in glucose homeostasis ...
Cited by 42 - Related articles - All 5 versions

Cellular mechanisms of insulin resistance, lipodystrophy and atherosclerosis induced by HIV …


A Rudich, R Ben-Romano, S Etzion, N … - Acta Physiologica Scandinavica, 2005 - interscience.wiley.com
Accumulating clinical evidence now links HIV protease inhibitors (HPIs) to the
pathogenesis of insulin resistance, dyslipidaemia, lipodystrophy and
atherosclerosis associated with highly active anti-retroviral therapy. Here ...
Cited by 34 - Related articles - All 3 versions


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