- ►diabetesjournals.org DJ Drucker - Diabetes Care, 2003 - Am Diabetes Assoc RESULTS—Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide
(GIP) exert important effects on β-cells to stimulate glucose-dependent insulin secretion. Both
peptides also regulate β-cell proliferation and cytoprotection. GLP-1, but not GIP, inhibits ... Cited by 284 - Related articles - All 13 versions
P Aschner, MS Kipnes, JK Lunceford, M Sanchez, … - Diabetes Care, 2006 - Am Diabetes Assoc RESULTS—Sitagliptin 100 and 200 mg produced significant (P < 0.001) placebo-subtracted
reductions in A1C (−0.79 and −0.94%, respectively) and fasting plasma glucose (−1.0
mmol/l [−17.1 mg/dl] and −1.2 mmol/l [−21.3 mg/dl], respectively). Patients with baseline ... Cited by 195 - Related articles - BL Direct - All 13 versions
AM Lambeir, C Durinx, S Scharpé, I De … - Critical reviews in …, 2003 - informahealthcare.com Laboratory of Medical Biochemistry, University of Antwerp, Universiteitsplein 1, Wilrijk, Belgium ... Referee: Dr. Albert Adam, Faculté de Pharmace, Université de Montréal, 2900 Blvd.
Edouard—Montpetit, CP succursale Centreville, Montreal, Quebec H3C 3J7, Canada Cited by 168 - Related articles - BL Direct - All 9 versions
- ►januvia.se [PDF] I Raz, M Hanefeld, L Xu, C Caria, D Williams-Herman, … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis The aim of this study was to assess the efficacy and safety of sitagliptin
(MK-0431) as mono- therapy in patients with type 2 diabetes mellitus and inadequate glycaemic
control (HbA 1c Q7% and e10%) on exercise and diet. Methods A total of 521 patients ... Cited by 167 - Related articles - All 5 versions
- ►diabetesjournals.org CF Deacon - Diabetes, 2004 - Am Diabetes Assoc Glucagon-like peptide (GLP)-1 is an incretin hormone with potent glucose-dependent insulinotropic
and glucagonostatic actions, trophic effects on the pancreatic β-cells, and inhibitory effects on
gastrointestinal secretion and motility, which combine to lower plasma glucose and ... Cited by 155 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org J Mu, J Woods, YP Zhou, RS Roy, Z Li, E Zycband, Y … - Diabetes, 2006 - Am Diabetes Assoc Inhibitors of dipeptidyl peptidase-4 (DPP-4), a key regulator of the actions of incretin
hormones, exert antihyperglycemic effects in type 2 diabetic patients. A major unanswered question
concerns the potential ability of DPP-4 inhibition to have beneficial disease-modifying ... Cited by 127 - Related articles - BL Direct - All 9 versions
JJ Holst - Diabetes/Metabolism Reviews - interscience.wiley.com GLP-1 is a peptide hormone from the intestinal mucosa. It is secreted in response to meal ingestion
and normally functions in the so-called ileal brake, that is, inhibition of upper gastrointestinal
motility and secretion when nutrients are present in the distal small intestine. It also ... Cited by 120 - Related articles - BL Direct - All 4 versions
DJ Drucker - eid, 2003 - informahealthcare.com Incretins are peptide hormones, exemplified by glucose-dependent insulino- tropic peptide and
glucagon-like peptide 1 that are released from the gut in response to nutrient ingestion and enhance
glucose-stimulated insulin secre- tion. Incretin action is terminated due to N-terminal ... Cited by 118 - Related articles - All 6 versions
- ►diabetesjournals.org T Hansotia, LL Baggio, D Delmeire, SA Hinke, Y … - Diabetes, 2004 - Am Diabetes Assoc Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are
gut-derived incretins that potentiate glucose clearance following nutrient ingestion. Elimination
of incretin receptor action in GIPR −/− or GLP-1R −/− mice produces only modest ... Cited by 110 - Related articles - BL Direct - All 13 versions
- ►diabetesjournals.org JA Pospisilik, SG Stafford, HU Demuth, CHS McIntosh, … - Diabetes, 2002 - Am Diabetes Assoc Upon release into circulation, the potent insulin secretagogues glucose-dependent insulinotropic
polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are rapidly cleaved and inactivated by
the enzyme dipeptidyl peptidase IV (DP IV). Long-term administration of specific DP IV ... Cited by 99 - Related articles - BL Direct - All 6 versions
