I Franklin, J Gromada, A Gjinovci, S … - Diabetes, 2005 - Am Diabetes Assoc Glucagon, secreted from islet α-cells, mobilizes liver glucose. During
hyperglycemia, glucagon secretion is inhibited by paracrine factors from other
islet cells, but in type 1 and type 2 diabetic patients, this suppression ... Cited by 74 - Related articles - All 4 versions
MC Riddle, DJ Drucker - Diabetes Care, 2006 - Am Diabetes Assoc Current therapies for type 2 diabetes are frequently associated with inadequate
control of postprandial hyperglycemia, weight gain, and, in the case of oral
agents, loss of efficacy over time. A better understanding of physiological ... Cited by 72 - Related articles - BL Direct - All 10 versions
A Suzuki, H Nakauchi, H Taniguchi - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences Glucagon-like peptide (GLP) 1 is produced through posttranslational processing
of proglucagon and acts as a regulator of various homeostatic events. Among its
analogs, however, the function of GLP-1-(1–37), synthesized in small ... Cited by 68 - Related articles - All 9 versions
- ►endojournals.org J Gromada, I Franklin, CB Wollheim - Endocrine reviews, 2007 - Endocrine Soc Glucagon, a hormone secreted from the -cells of the endocrine pancreas, is
critical for blood glucose homeostasis. It is the major counterpart to insulin
and is released during hypoglycemia to induce hepatic glucose output. The ... Cited by 61 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org FK Knop, T Vilsbøll, PV Højberg, S Larsen, S … - Diabetes, 2007 - Am Diabetes Assoc We aimed to investigate whether the reduced incretin effect observed in patients
with type 2 diabetes is a primary event in the pathogenesis of type 2 diabetes
or a consequence of the diabetic state. Eight patients with chronic ... Cited by 38 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org NA Sherry, EB Tsai, KC Herold - Diabetes, 2005 - Am Diabetes Assoc Despite extensive and ongoing investigations of the immune mechanisms of
autoimmune diabetes in humans and animal models, there is much less information
about the natural history of insulin secretion before and after the ... Cited by 37 - Related articles - BL Direct - All 6 versions
- ►physiology.org N Pamir, FC Lynn, AMJ Buchan, J Ehses, SA … - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc The incretins glucose-dependent insulinotropic polypeptide (GIP) and
glucagon-like peptide-1 (GLP-1) are gut hormones that act via the enteroinsular
axis to potentiate insulin secretion from the pancreas in a ... Cited by 31 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org J Shao, L Qiao, RC Janssen, M Pagliassotti, … - Diabetes, 2005 - Am Diabetes Assoc Acute hyperglycemia normally suppresses hepatic glucose production (HGP) and
gluconeogenic gene expression. Conversely, chronic hyperglycemia is accompanied
by progressive increases in basal HGP and is a major contributor to ... Cited by 29 - Related articles - All 5 versions
- ►diabetesjournals.org C Eftychi, JMM Howson, BJ Barratt, A Vella, … - Diabetes, 2004 - Am Diabetes Assoc It has been proposed that type 1 and 2 diabetes might share common
pathophysiological pathways and, to some extent, genetic background. However, to
date there has been no convincing data to establish a molecular genetic ... Cited by 21 - Related articles - BL Direct - All 5 versions
- ►endojournals.org NA Sherry, W Chen, JA Kushner, M Glandt, Q … - Endocrinology, 2007 - Endocrine Soc Immune modulators can arrest loss of insulin secretion in type 1 diabetes
mellitus (T1DM), but they have not caused permanent disease remission or
restored normal insulin secretion. We tested whether exendin-4, a ... Cited by 25 - Related articles - BL Direct - All 5 versions
