- ►diabetesjournals.org PE Cryer, SN Davis, H Shamoon - Diabetes Care, 2003 - Am Diabetes Assoc Iatrogenic hypoglycemia causes recurrent morbidity in most people with type 1 diabetes and
many with type 2 diabetes, and it is sometimes fatal. The barrier of hypoglycemia generally precludes
maintenance of euglycemia over a lifetime of diabetes and thus precludes full realization ... Cited by 373 - Related articles - All 8 versions
P Cryer - Diabetologia, 2002 - Springer Hypoglycaemia is the limiting factor in the glycaemic management of diabetes. Iatrogenic hypoglycaemia
is typically the result of the interplay of insulin excess and compromised glucose counterregulation
in Type I (insulin-dependent) diabetes mellitus. Insulin concen- trations do not decrease ... Cited by 225 - Related articles - BL Direct - All 6 versions
- ►shouxi.net PE Cryer - New England Journal of Medicine, 2004 - content.nejm.org In this article, I discuss the clinical problem of hypoglycemia in diabetes from the perspective
of pathophysiology. First, the syndromes of defective glucose counterregulation and hypoglycemia
without warning symptoms (known as "hypoglycemia unawareness") are described, ... Cited by 156 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org NN Zammitt, BM Frier - Diabetes Care, 2005 - Am Diabetes Assoc The importance of strict glycemic control to limit the risk of diabetic vascular complications is
indisputable, but many barriers obstruct its attainment. Hypoglycemia is recognized to be a major
limitation in achieving good control in type 1 diabetes (1) but has been considered to be a ... Cited by 89 - Related articles - All 6 versions
I Franklin, J Gromada, A Gjinovci, S Theander, CB … - Diabetes, 2005 - Am Diabetes Assoc Glucagon, secreted from islet α-cells, mobilizes liver glucose. During hyperglycemia, glucagon
secretion is inhibited by paracrine factors from other islet cells, but in type 1 and type 2 diabetic
patients, this suppression is lost. We investigated the effects of β-cell secretory products ... Cited by 74 - Related articles - All 4 versions
- ►diabetesjournals.org ML Evans, RJ McCrimmon, DE Flanagan, T Keshavarz, … - Diabetes, 2004 - Am Diabetes Assoc It has been postulated that specialized glucose-sensing neurons in the ventromedial hypothalamus
(VMH) are able to detect falling blood glucose and trigger the release of counterregulatory hormones
during hypoglycemia. The molecular mechanisms used by glucose-sensing neurons are ... Cited by 74 - Related articles - BL Direct - All 5 versions
PE Cryer - Diabetes, 2005 - Am Diabetes Assoc Iatrogenic hypoglycemia is a problem for people with diabetes. It causes recurrent morbidity,
and sometimes death, as well as a vicious cycle of recurrent hypoglycemia, precluding maintenance
of euglycemia over a lifetime of diabetes. Improved therapeutic approaches that will ... Cited by 75 - Related articles - BL Direct - All 7 versions
B Raju, PE Cryer - Diabetes, 2005 - Am Diabetes Assoc The intraislet insulin hypothesis for the signaling of the glucagon secretory response to hypoglycemia
states that a decrease in arterial glucose → a decrease in β-cell insulin secretion → a decrease
in tonic α-cell inhibition by insulin → an increase in α-cell glucagon secretion. To test this ... Cited by 60 - Related articles - All 6 versions
- ►endojournals.org J Gromada, I Franklin, CB Wollheim - Endocrine reviews, 2007 - Endocrine Soc Glucagon, a hormone secreted from the -cells of the endocrine pancreas, is critical for blood
glucose homeostasis. It is the major counterpart to insulin and is released during hypoglycemia
to induce hepatic glucose output. The control of glucagon secretion is multifactorial and ... Cited by 61 - Related articles - BL Direct - All 4 versions
KM Hope, POT Tran, H Zhou, E Oseid, E Leroy, RP … - Diabetes, 2004 - Am Diabetes Assoc The “switch-off” hypothesis to explain β-cell regulation of α-cell function during hypoglycemia
has not been assessed previously in isolated islets, largely because they characteristically do
not respond to glucose deprivation by secreting glucagon. We examined this hypothesis ... Cited by 43 - Related articles - BL Direct - All 4 versions
