- ►jbc.org Y Lin, AH Berg, P Iyengar, TKT Lam, A Giacca, TP … - Journal of Biological …, 2005 - ASBMB Hyperglycemia is a major independent risk factor for diabetic macrovascular disease. The
consequences of exposure of endothelial cells to hyperglycemia are well established. However, little
is known about how adipocytes ... Cited by 152 - Related articles - All 6 versions
CE Wrede, LM Dickson, MK Lingohr, I Briaud, CJ … - Journal of Biological …, 2002 - ASBMB Free fatty acids (FFA) have been reported to reduce pancreatic -cell mitogenesis and to increase
apoptosis. Here we show that the FFA, oleic acid, increased apoptosis 16-fold in the pancreatic
-cell line, INS-1, over a 18-h ... Cited by 127 - Related articles - BL Direct - All 6 versions
MK Lingohr, R Buettner, CJ Rhodes - Trends in molecular medicine, 2002 - Elsevier Obesity-linked type 2 diabetes is a disease of insulin resistance combined with pancreatic β-cell
dysfunction. Although a role for β-cell mass in the pathogenesis of obesity-linked type 2 diabetes
has recently gained prominence, the ... Cited by 91 - Related articles - All 7 versions
J Dupont, M Holzenberger - BIRTH DEFECTS RESEARCH …, 2003 - interscience.wiley.com Insulin-like growth factors (IGFs) provide essential signals for the control of embryonic and
postnatal development in vertebrate species. In mammals, IGFs act through and are regulated by a
system of receptors, binding ... Cited by 77 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org I Briaud, MK Lingohr, LM Dickson, CE Wrede, CJ … - Diabetes, 2003 - Am Diabetes Assoc Glucose can activate the mitogen-activated kinases, Erk-1/2, and the ribosomal-S6 kinase, p70 S6K ,
in β-cells, contributing to an increase in mitogenesis. However, the signaling mechanism by which
glucose induces Erk-1/2 and p70 S6K ... Cited by 78 - Related articles - BL Direct - All 4 versions
AM Vincent, BC Mobley, A Hiller, EL Feldman - Neurobiology of disease, 2004 - Elsevier Insulin-like growth factor I (IGF-I) is currently in clinical trials for treatment of amyotrophic
lateral sclerosis (ALS), but little is known about how it promotes the survival of motor neurons. In
the current study, we examined ... Cited by 65 - Related articles - All 3 versions
B Wicksteed, C Alarcon, I Briaud, MK Lingohr, CJ … - Journal of Biological …, 2003 - ASBMB Proinsulin biosynthesis is regulated in response to nutrients, most notably glucose. In the short
term ( 2h) this is due to increases in the translation of pre-existing mRNA. However, prolonging
glucose stimulation (24 h) also ... Cited by 62 - Related articles - BL Direct - All 4 versions
- ►jhc.org KD Niswender, B Gallis, JE Blevins, MA … - … of Histochemistry and …, 2003 - Histochemical Soc Intracellular signaling mediated by phosphatidylinositol 3-kinase (PI3K) is important for a number
of cellular processes and is stimulated by a variety of hormones, including insulin and leptin. A
histochemical method for assessment ... Cited by 60 - Related articles - BL Direct - All 4 versions
- ►physiology.org LM Dickson, CJ Rhodes - American Journal of Physiology- …, 2004 - Am Physiological Soc The control of pancreatic -cell growth and survival in the adult plays a pivotal role in the
pathogenesis of type 2 diabetes. In certain insulin-resistant states, such as obesity, the increased
insulin-secretory demand can often ... Cited by 59 - Related articles - BL Direct - All 3 versions
MJ Donelan, G Morfini, R Julyan, S Sommers, L … - Journal of Biological …, 2002 - ASBMB The specific biochemical steps required for glucose-regulated insulin exocytosis from -cells are not
well defined. Elevation of glucose leads to increases in cytosolic [Ca 2+ ] i and biphasic release
of insulin from both a readily ... Cited by 48 - Related articles - BL Direct - All 5 versions
