- ►endojournals.org I Kharroubi, L Ladriere, AK Cardozo, Z … - Endocrinology, 2004 - Endocrine Soc Apoptosis is probably the main form of ß-cell death in both type 1 diabetes
mellitus (T1DM) and T2DM. In T1DM, cytokines contribute to ß-cell destruction
through nuclear factor- B (NF- B) activation. Previous studies suggested ... Cited by 134 - Related articles - BL Direct - All 3 versions
- ►pubget.com [PDF] DR Laybutt, AM Preston, MC Åkerfeldt, JG … - Diabetologia, 2007 - Springer Page 1. ARTICLE Endoplasmic reticulum stress contributes to beta cell apoptosis
in type 2 diabetes DR Laybutt & AM Preston & MC Åkerfeldt & ... Cited by 103 - Related articles - BL Direct - All 5 versions
- ►endojournals.org E Karaskov, C Scott, L Zhang, T Teodoro, M … - Endocrinology, 2006 - Endocrine Soc Chronic free fatty acid (FFA) exposure induces pancreatic ß-cell death, which
may contribute to the development of type 2 diabetes. The mechanisms involved in
FFA-induced cell death are not completely understood. Here we have ... Cited by 95 - Related articles - BL Direct - All 4 versions
- ►nih.gov MG Hartman, D Lu, ML Kim, GJ Kociba, T … - Molecular and Cellular Biology, 2004 - Am Soc Microbiol Activating transcription factor 3 (ATF3) is a stress-inducible gene and encodes
a member of the ATF/CREB family of transcription factors. However, the
physiological significance of ATF3 induction by stress signals is not ... Cited by 85 - Related articles - BL Direct - All 11 versions
- ►diabetesjournals.org CB Chan, MC Saleh, V Koshkin, MB Wheeler - Diabetes, 2004 - Am Diabetes Assoc Stressors such as chronic hyperglycemia or hyperlipidemia may lead to
insufficient insulin secretion in susceptible individuals, contributing to type
2 diabetes. The molecules mediating this effect are just beginning to be ... Cited by 83 - Related articles - BL Direct - All 4 versions
- ►psu.edu [PDF] H Lan, ME Rabaglia, JP Stoehr, ST Nadler, KL … - Diabetes, 2003 - Am Diabetes Assoc Obesity is a strong risk factor for the development of type 2 diabetes. We have
previously reported that in adipose tissue of obese (ob/ob) mice, the expression
of adipogenic genes is decreased. When made genetically obese, the BTBR ... Cited by 77 - Related articles - BL Direct - All 15 versions
CL Kelpe, PC Moore, SD Parazzoli, B … - Journal of Biological Chemistry, 2003 - ASBMB Chronic exposure to elevated levels of fatty acids impairs pancreatic beta cell
function, a phenomenon thought to contribute to the progressive deterioration of
insulin secretion in type 2 diabetes. We have previously demonstrated that ... Cited by 66 - Related articles - BL Direct - All 6 versions
- ►endojournals.org V Poitout, RP Robertson - Endocrine reviews, 2008 - Endocrine Soc Glucotoxicity, lipotoxicity, and glucolipotoxicity are secondary phenomena that
are proposed to play a role in all forms of type 2 diabetes. The underlying
concept is that once the primary pathogenesis of diabetes is established, ... Cited by 68 - Related articles - BL Direct - All 7 versions
V Koshkin, X Wang, PE Scherer, CB Chan, … - Journal of Biological Chemistry, 2003 - ASBMB Excessive free fatty acid (FFA) exposure represents a potentially important
diabetogenic condition that can impair insulin secretion from pancreatic -cells.
Because mitochondrial oxidative phosphorylation is a main link between ... Cited by 64 - Related articles - BL Direct - All 5 versions
X Wang, H Li, D De Leo, W Guo, V Koshkin, … - Diabetes, 2004 - Am Diabetes Assoc Gene and Protein Kinase Expression Profiling of ... Reactive Oxygen
Species–Associated Lipotoxicity in the ... Xiaolin Wang, 1 * Hui Li, 1,2 *
Domenica De Leo, 1 Wanbei Guo, 2 Vasilij Koshkin, 1 I. George Fantus, 1,3 Cited by 50 - Related articles - BL Direct - All 4 versions
