S Del Guerra, R Lupi, L Marselli, M Masini, M Bugliani, … - Diabetes, 2005 - Am Diabetes Assoc To shed further light on the primary alterations of insulin secretion in type 2 diabetes and the
possible mechanisms involved, we studied several functional and molecular properties of islets
isolated from the pancreata of 13 type 2 diabetic and 13 matched nondiabetic cadaveric ... Cited by 107 - Related articles - All 5 versions
S Deng, M Vatamaniuk, X Huang, N Doliba, MM Lian, A … - Diabetes, 2004 - Am Diabetes Assoc Type 2 diabetic subjects manifest both disordered insulin action and abnormalities in their pancreatic
islet cells. Whether the latter represents a primary defect or is a consequence of the former is
unknown. To examine the β-cell mass and function of islets from type 2 diabetic patients ... Cited by 96 - Related articles - BL Direct - All 4 versions
- ►endojournals.org P Marchetti, S Del Guerra, L Marselli, R Lupi, M … - Journal of Clinical …, 2004 - Endocrine Soc Several properties of pancreatic ß-cells in type 2 diabetes (T2D) were studied by using islets
isolated from T2D subjects. Moreover, because metformin has protective effects on nondiabetic
ß-cells exposed to high glucose or free fatty acid levels, we investigated its direct action ... Cited by 92 - Related articles - BL Direct - All 5 versions
P Marchetti, M Bugliani, R Lupi, L Marselli, M Masini, U … - Diabetologia, 2007 - Springer Page 1. ARTICLE The endoplasmic reticulum in pancreatic beta cells of type 2
diabetes patients P. Marchetti & M. Bugliani & R. Lupi & L. Marselli & M. Masini &
U. Boggi & F. Filipponi & GC Weir & DL Eizirik & M. Cnop Received ... Cited by 47 - Related articles - BL Direct - All 2 versions
RA Ritzel, JJ Meier, CY Lin, JD Veldhuis, PC Butler - Diabetes, 2007 - Am Diabetes Assoc Insulin secretion from the 2,000–3,000 β-cells in an islet is a highly synchronized activity with
discharge of insulin in coordinate secretory bursts at approximately 4-min intervals. Insulin secretion
progressively declines in type 2 diabetes and following islet transplantation. Both are ... Cited by 28 - Related articles - BL Direct - All 5 versions
P Marchetti, S Del Prato, R Lupi, S Del Guerra - Nutrition, Metabolism and …, 2006 - Elsevier Several genes have been associated with islet cell dysfunction in Type 2 diabetes, including
those encoding for transcription factors, glucose metabolism proteins, molecules of the insulin
signaling pathways, and several others. On the other hand, many environmental factors ... Cited by 30 - Related articles - All 5 versions
- ►endojournals.org RA Ritzel, JD Veldhuis, PC Butler - Journal of Clinical Endocrinology & …, 2003 - Endocrine Soc INSULIN IS SECRETED in a glucose-regulated manner (1, 2). Insulin release is pulsatile with
an interpulse interval of approximately 6 min (3, 4). In vivo insulin secretion in response to glucose
ingestion and glucose infusion is driven by amplification of insulin pulse mass with no or ... Cited by 21 - Related articles - BL Direct - All 5 versions
- ►hawaii.edu [PDF] H Cheng, A Beck, P Launay, SA Gross, AJ Stokes, JP … - Cell Calcium, 2007 - Elsevier TRPM4 is a calcium-activated non-selective cation channel that is widely expressed and proposed
to be involved in cell depolarization. In excitable cells, TRPM4 may regulate calcium influx by
causing the depolarization that drives the activation of voltage-dependent calcium ... Cited by 20 - Related articles - All 4 versions
P Marchetti, F Dotta, D Lauro, F Purrello - Regulatory Peptides, 2008 - Elsevier Type 2 diabetes is the most common form of diabetes in humans. It results from a combination
of factors that impair beta-cell function and tissue insulin sensitivity. However, growing evidence
is showing that the beta-cell is central to the development and progression of this form of ... Cited by 16 - Related articles - All 3 versions
- ►numesi.com [PDF] B Portha, G Lacraz, M Kergoat, F Homo-Delarche, … - Molecular and Cellular …, 2009 - Elsevier Increasing evidence indicates that decreased functional beta-cell mass is the hallmark of type
2 diabetes (T2D) mellitus. Nowadays, the debate focuses on the possible mechanisms responsible
for abnormal islet microenvironment, decreased beta-cell number, impaired beta-cell ... Cited by 6 - Related articles - All 3 versions
