- ►jbc.org G Kang, JW Joseph, OG Chepurny, M Monaco, … - Journal of Biological Chemistry, 2003 - ASBMB The second messenger cAMP exerts powerful stimulatory effects on Ca 2+ signaling
and insulin secretion in pancreatic -cells. Previous studies of -cells focused
on protein kinase A (PKA) as a downstream effector of cAMP action. However, ... Cited by 146 - Related articles - BL Direct - All 23 versions
- ►diabetesjournals.org GG Holz - Diabetes, 2004 - Am Diabetes Assoc Recently published studies of islet cell function reveal unexpected features of
glucagon-like peptide-1 (GLP-1) receptor-mediated signal transduction in the
pancreatic β-cell. Although GLP-1 is established to be a cAMP-elevating ... Cited by 127 - Related articles - BL Direct - All 6 versions
- ►jbc.org JD Johnson, Z Han, K Otani, H Ye, Y Zhang, H … - Journal of Biological Chemistry, 2004 - ASBMB Cells are programmed to die when critical signaling and metabolic pathways are
disrupted. Inhibiting the type 2 ryanodine receptor (RyR2) in human and mouse
pancreatic -cells markedly increased apoptosis. This mode of programmed ... Cited by 65 - Related articles - BL Direct - All 5 versions
D Rossi, V Sorrentino - Cell Calcium, 2002 - Elsevier The family of ryanodine receptor (RyR) genes encodes three highly related Ca 2+
-release channels: RyR1, RyR2 and RyR3. RyRs are known as the Ca 2+ -release
channels that participate to the mechanism of excitation–contraction ... Cited by 53 - Related articles - BL Direct - All 3 versions
- ►shouxi.net G Kang, OG Chepurny, MJ Rindler, L Collis, … - The Journal of Physiology, 2005 - Physiological Soc The blood glucose-lowering hormone glucagon-like peptide-1 (GLP-1) stimulates
cAMP production, promotes Ca 2+ influx, and mobilizes an intracellular source of
Ca 2+ in pancreatic β cells. Here we provide evidence that these actions ... Cited by 51 - Related articles - All 18 versions
- ►physoc.org G Kang, GG Holz - The Journal of Physiology, 2003 - Physiological Soc Functional coupling between Ca 2+ -induced Ca 2+ release (CICR) and quantal
exocytosis in 5-hydroxytryptamine-loaded INS-1 β cells was assessed through the
use of carbon fibre amperometry in combination with Fura-2. CICR was evoked ... Cited by 38 - Related articles - BL Direct - All 16 versions
NJ Pyne, BL Furman - Diabetologia, 2003 - Springer Cyclic nucleotide phosphodiesterases (PDEs) com- prise a family of enzymes
(PDE1-PDE11) which hy- drolyse cyclic AMP and cyclic GMP to their biologi- cally
inactive 5′ derivatives. Cyclic AMP is an impor- tant physiological ... Cited by 36 - Related articles - BL Direct - All 5 versions
- ►fasebj.org [PDF] JD Bruton, R Lemmens, CL Shi, S Persson- … - The FASEB Journal, 2002 - FASEB *Department of Physiology, Karolinska Institutet, Stockholm, Sweden;
†Department of Molecular Medicine, Karolinska Institutet, Department of
Endocrinology, Karolinska Hospital, Stockholm, Sweden; flDepartment of ... Cited by 35 - Related articles - BL Direct - All 5 versions
GA Rutter, T Tsuboi, MA Ravier - Cell Calcium, 2006 - Elsevier Nutrient-induced increases in intracellular free Ca 2+ concentrations are the
key trigger for insulin release from pancreatic islet β-cells. These Ca 2+
changes are tightly regulated temporally, occurring as Ca 2+ ... Cited by 22 - Related articles - All 4 versions
CH George, CC Yin, FA Lai - Cell biochemistry and biophysics, 2005 - Springer The precise control of intracellular levels of free calcium (Ca 2+ ) regulates a
vast array of homeostatic cellular processes via complex spa- tiotemporal
encryption of cytosolic Ca 2+ signals (1–7). Ca 2+ release from ... Cited by 17 - Related articles - BL Direct - All 4 versions
