- ►endocrinology-journals.org K Wynne, S Stanley, B McGowan, S … - Journal of Endocrinology, 2005 - Soc Endocrinology Our understanding of the physiological systems that regulate food intake and body weight has
increased immensely over the past decade. Brain centres, including the hypothalamus, brainstem
and reward centres, signal via neuropeptides which regulate energy homeostasis. Insulin ... Cited by 173 - Related articles - All 4 versions
- ►rockefeller.edu [PDF] SF Leibowitz, KE Wortley - Peptides, 2004 - Elsevier Energy balance is maintained via a homeostatic system involving both the brain and the
periphery. A key component of this system is the hypothalamus. Over the past two decades, major
advances have been made in identifying an increasing number of peptides within the ... Cited by 104 - Related articles - All 7 versions
- ►endojournals.org H Munzberg, L Huo, EA Nillni, AN Hollenberg, C … - Endocrinology, 2003 - Endocrine Soc Leptin acts on the brain to regulate body weight and neuroendocrine function. Proopiomelanocortin
(POMC) neurons in the hypothalamus are important targets of leptin. These cells express the
leptin receptor ObRb, and leptin can regulate POMC mRNA levels, but the cellular ... Cited by 104 - Related articles - BL Direct - All 3 versions
- ►physiology.org S Stanley, K Wynne, B McGowan, S … - Physiological reviews, 2005 - Am Physiological Soc Our knowledge of the physiological systems controlling energy homeostasis has increased dramatically
over the last decade. The roles of peripheral signals from adipose tissue, pancreas, and the gastrointestinal
tract reflecting short- and long-term nutritional status are now being described. Such ... Cited by 88 - Related articles - BL Direct - All 7 versions
- ►endojournals.org DL Marks, AA Butler, R Turner, G Brookhart, RD Cone - Endocrinology, 2003 - Endocrine Soc Animals and humans respond to starvation with a complex neuroendocrine response that ultimately
leads to an increase in appetite, a sparing of lean body mass (LBM) and burning of fat, and an
overall decrease in basal metabolic rate. In contrast, cachexia is a pathological state of ... Cited by 68 - Related articles - BL Direct - All 3 versions
- ►endojournals.org H Shinyama, H Masuzaki, H Fang, JS Flier - Endocrinology, 2003 - Endocrine Soc Disruption of the hypothalamic melanocortin-4 receptor (MC4R) pathway results in obesity both
in humans and rodents, demonstrating a crucial role for hypothalamic MC4Rs in the regulation
of energy homeostasis. Because even haploinsufficiency of the MC4R gene can cause ... Cited by 63 - Related articles - BL Direct - All 3 versions
- ►cell.com PJ Enriori, AE Evans, P Sinnayah, EE Jobst, L Tonelli- … - Cell Metabolism, 2007 - Elsevier Despite high leptin levels, most obese humans and rodents lack responsiveness to its
appetite-suppressing effects. We demonstrate that leptin modulates NPY/AgRP and α-MSH secretion
from the ARH of lean mice. High-fat diet-induced obese (DIO) mice have normal ObRb ... Cited by 69 - Related articles - All 11 versions
S Blüher, M Ziotopoulou, JW Bullen, SJ Moschos, L … - Diabetes, 2004 - Am Diabetes Assoc To elucidate mechanisms of melanocortin action, we investigated the effects of a melanocortin
receptor agonist (melanotetan II [MTII]) in lean C57BL/6J and obese (DIO, ob/ob,
UCP1-DTA) mice. MTII administration (100 μg qidip) for 24 h results in similar weight loss ... Cited by 53 - Related articles - BL Direct - All 5 versions
- ►nih.gov AA Butler - Peptides, 2006 - Elsevier The melanocortins, a family of peptides produced from the post-translational processing of
pro-opiomelanocortin (POMC), regulate ingestive behavior and energy expenditure. Loss of
function mutations of genes encoding POMC, or of either of two melanocortin receptors ... Cited by 48 - Related articles - All 6 versions
- ►physiology.org JH Lee, JW Bullen Jr, VL Stoyneva, CS … - American Journal of …, 2005 - Am Physiological Soc Resistin is an adipocyte-secreted hormone proposed to link obesity with insulin resistance and
diabetes, but no previous study has performed a joint quantitative evaluation of white adipose
tissue (WAT) resistin mRNA expression and serum levels in relation to insulinemia and ... Cited by 47 - Related articles - All 4 versions
