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Scholar Results 1 - 10 of about 72 citing Graham: Genetic effects on age-dependent onset and islet cell autoantibody markers in type.... (0.08 sec) 

Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel …


AJ MacMurray, DH Moralejo, AE Kwitek, EA … - Genome …, 2002 - genome.cshlp.org
The BB (BioBreeding) rat is one of the best models of spontaneous autoimmune diabetes and
is used to study non-MHC loci contributing to Type 1 diabetes. Type 1 diabetes in the
diabetes-prone BB (BBDP) rat is polygenic, dependent upon mutations at several ...
Cited by 112 - Related articles - BL Direct - All 12 versions

The emerging role of the CTLA-4 gene in autoimmune endocrinopathies

- eje-online.org [PDF] 
B Vaidya, S Pearce - European Journal of Endocrinology, 2004 - EFES
It is thought that the majority of autoimmune endocrinopathies, including Graves' disease,
auto- immune hypothyroidism, type 1 diabetes mellitus and autoimmune Addison's disease
(sporadic and as well as autoimmune polyendocrinopathy syndrome type 2) are inherited ...
Cited by 74 - Related articles - BL Direct - All 8 versions

Ketosis-Prone Diabetes: Dissection of a Heterogeneous Syndrome Using an …

- endojournals.org
M Maldonado, CS Hampe, LK Gaur, S D'Amico, … - Journal of Clinical …, 2003 - Endocrine Soc
Ketosis-prone diabetes is heterogeneous. Its causes could include novel ß-cell functional
defects. To characterize such defects, 103 patients with diabetic ketoacidosis were evaluated
for ß-cell autoimmunity and human leukocyte antigen (HLA) class II alleles, with ...
Cited by 70 - Related articles - BL Direct - All 4 versions

Autoantibodies in diabetes

- diabetesjournals.org
C Pihoker, LK Gilliam, CS Hampe, Å Lernmark - Diabetes, 2005 - Am Diabetes Assoc
Islet cell autoantibodies are strongly associated with the development of type 1 diabetes. The
appearance of autoantibodies to one or several of the autoantigens—GAD65, IA-2, or
insulin—signals an autoimmune pathogenesis of β-cell killing. A β-cell attack may be best ...
Cited by 53 - Related articles - BL Direct - All 6 versions

Genetics of autoimmune diseases in humans and in animal models


G Morahan, L Morel - Current opinion in immunology, 2002 - Elsevier
Why are some people better able to overcome infectious diseases than others? Why is it that
in some people these normally protective responses go awry so they develop autoimmune
diseases? Over the last two decades there have been tremendous advances in our ...
Cited by 50 - Related articles - All 5 versions

IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of …


M Walter, E Albert, M Conrad, E Keller, M Hummel, K … - Diabetologia, 2003 - Springer
Aim/hypothesis. Type 1 diabetes (T1D) is an autoim- mune disease with multiple susceptibility
genes. The aim of this study was to determine whether combining IDDM1/HLA and IDDM2/insulin
(INS) 5′ variable number of tandem repeat locus (VNTR) genotypes improves T1D risk ...
Cited by 41 - Related articles - BL Direct - All 3 versions

Natural history of type 1 diabetes

- diabetesjournals.org
P Achenbach, E Bonifacio, K Koczwara, AG Ziegler - Diabetes, 2005 - Am Diabetes Assoc
The natural history of autoimmune type 1 diabetes in children is associated with the appearance
of islet autoantibodies early in life, which is influenced by genetic and environmental factors.
Once islet autoantibodies have developed, the progression to diabetes in ...
Cited by 37 - Related articles - BL Direct - All 9 versions

Association between the transmembrane region polymorphism of MHC class I …


M Gupta, L Nikitina-Zake, M Zarghami, M Landin- … - Human immunology, 2003 - Elsevier
Major histocompatibility complex (MHC) class I chain related gene-A (MIC-A) is associated with
type 1 diabetes mellitus (T1DM) in other populations. We tested the association of MIC-A gene
polymorphism with T1DM in Swedish Caucasians; if it has an age-dependent association; ...
Cited by 31 - Related articles - All 4 versions

Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates …


R Hermann, K Lipponen, M Kiviniemi, T Kakko, R … - Diabetologia, 2006 - Springer
Page 1. Diabetologia (2006) 49: 1198–1208 DOI 10.1007/s00125-006-0225-4 ARTICLE
R. Hermann . K. Lipponen . M. Kiviniemi . T. Kakko . R. Veijola . O. Simell . M. Knip . J. Ilonen
Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant ...
Cited by 27 - Related articles - BL Direct - All 4 versions

Combined positivity for HLA DQ2/DQ8 and IA-2 antibodies defines population at …

- bdronline.be [PDF] 
K Decochez, I Truyen, B Van der Auwera, I Weets, E … - Diabetologia, 2005 - Springer
Page 1. Diabetologia (2005) 48: 687–694 DOI 10.1007/s00125-005-1702-x ARTICLE K. Decochez
. I. Truyen . B. Van der Auwera . I. Weets . E. Vandemeulebroucke . IH De Leeuw . B. Keymeulen .
C. Mathieu . R. Rottiers . DG Pipeleers . FK Gorus . Belgian Diabetes Registry ...
Cited by 24 - Related articles - All 8 versions


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