- ►cnfindpark.cn MF Holick - American Journal of Clinical Nutrition, 2004 - ajcn.cnfindpark.cn The purpose of this review is to put into perspective the many health benefits of vitamin D and
the role of vitamin D deficiency in increasing the risk of many common and serious diseases,
including some common cancers, type 1 diabetes, cardiovascular disease, and ... Cited by 507 - Related articles - BL Direct - All 13 versions
- ►endojournals.org S Nagpal, S Na, R Rathnachalam - Endocrine reviews, 2005 - Endocrine Soc 1 ,25-Dihydroxyvitamin D 3 [1,25-(OH) 2 D 3 ], the active metabolite of vitamin D 3 , is known
for the maintenance of mineral homeostasis and normal skeletal architecture. However, apart
from these traditional calcium-related actions, 1,25-(OH) 2 D 3 and its synthetic analogs ... Cited by 203 - Related articles - BL Direct - All 5 versions
CE Hayes, FE Nashold, KM Spach, LB … - CELLULAR AND …, 2003 - direct-ms.org Abstract - The discoveries that activated macrophages produce 1α,25-dihydroxyvitamin D3
(1α,25-(OH)2D3), and that immune system cells express the vitamin D receptor (VDR), suggested
that the vitamin D endocrine system influences immune system function. In this review, we ... Cited by 142 - Related articles - BL Direct - All 4 versions
- ►sediabetes.org [PDF] C Mathieu, C Gysemans, A Giulietti, R Bouillon - Diabetologia, 2005 - Springer Abstract Vitamin D deficiency predisposes individuals to type 1 and type 2 diabetes, and receptors
for its activated form—1α,25-dihydroxyvitamin D 3 —have been identified in both beta cells and
immune cells. Vitamin D deficiency has been shown to impair insulin synthesis and ... Cited by 127 - Related articles - BL Direct - All 8 versions
- ►ebmonline.org MT Cantorna, BD Mahon - Experimental Biology and Medicine, 2004 - SEBM Low vitamin D status has been implicated in the etiology of autoimmune diseases such as multiple
sclerosis, rheumatoid arthritis, insulin-dependent diabetes mellitus, and inflammatory bowel
disease. The optimal level of vitamin D intake required to support optimal immune ... Cited by 121 - Related articles - BL Direct - All 5 versions
L Adorini, G Penna, N Giarratana, M … - Journal of cellular …, 2003 - interscience.wiley.com Dendritic cells (DCs) not only induce but also modulate T cell activation. 1,25-dihydroxyvitamin
D 3 [1,25(OH) 2 D 3 ] induces DCs with a tolerogenic phenotype, characterized by decreased
expression of CD40, CD80, and CD86 costimulatory molecules, low IL-12 and enhanced ... Cited by 103 - Related articles - BL Direct - All 6 versions
- ►endojournals.org M Froicu, V Weaver, TA Wynn, MA McDowell, JE … - Molecular …, 2003 - Endocrine Soc The active form of vitamin D (1,25D 3 ) suppressed the development of animal models of human
autoimmune diseases including experimental inflammatory bowel disease (IBD). The vitamin
D receptor (VDR) is required for all known biologic effects of vitamin D. Here we show that ... Cited by 98 - Related articles - BL Direct - All 5 versions
E Etten, C Mathieu - Journal of Steroid Biochemistry and Molecular Biology, 2005 - Elsevier 1,25-Dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ), the biologically active metabolite of Vitamin D 3
, not only regulates bone and calcium metabolism but also exerts other biological activities, including
immunomodulation via the nuclear Vitamin D receptor expressed in antigen-presenting ... Cited by 97 - Related articles - All 7 versions
L Adorini - International immunopharmacology, 2002 - Elsevier The active form of vitamin D, 1,25-Dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ], is a secosteroid hormone
that binds to the vitamin D receptor (VDR), a member of the superfamily of nuclear receptors
for steroid hormones, thyroid hormone, and retinoic acid. VDR ligands regulate calcium ... Cited by 90 - Related articles - All 3 versions
- ►jimmunol.org G Vlad, R Cortesini, N Suciu-Foca - The Journal of Immunology, 2005 - Am Assoc Immnol Naturally occurring CD4 + CD25 + regulatory T (T R ) cells, a component of the innate immune
response, which play a key role in the maintenance of self-tolerance, have become the focus
of numerous studies over the last decade. These cells inhibit the immune response in an ... Cited by 90 - Related articles - All 4 versions
