- ►rupress.org V Viglietta, C Baecher-Allan, HL Weiner, DA … - Journal of Experimental Medicine, 2004 - jem.rupress.org CD4 + CD25 + regulatory T cells contribute to the maintenance of peripheral
tolerance by active suppression because their deletion causes spontaneous
autoimmune diseases in mice. Human CD4 + regulatory T cells expressing high ... Cited by 677 - Related articles - BL Direct - All 8 versions
BO Roep - Diabetologia, 2003 - Springer Type 1 diabetes mellitus results from a T-cell mediat- ed autoimmune destruction
of the pancreatic beta cells in genetically predisposed individuals. The
knowledge of the immunopathogenesis has increased enormously in the last ... Cited by 139 - Related articles - BL Direct - All 5 versions
- ►jimmunol.org NA Danke, DM Koelle, C Yee, S Beheray, … - The Journal of Immunology, 2004 - Am Assoc Immnol The presence of autoreactive CD4 + T cells in the peripheral blood of healthy
human subjects was investigated after removal of CD4 + CD25 + regulatory T cells
(Treg). CD4 + T cells that were directed against the type 1 ... Cited by 119 - Related articles - BL Direct - All 7 versions
- ►pnas.org GGM Pinkse, OHM Tysma, CAM Bergen, MGD … - Proceedings of the National Academy of Sciences, 2005 - National Acad Sciences Type 1 diabetes is a T cell-mediated autoimmune disease, and insulin is an
important target of the autoimmune response associated with β cell destruction.
The mechanism of destruction is still unknown. Here, we provide evidence ... Cited by 87 - Related articles - BL Direct - All 10 versions
SM Lieberman, TP DiLorenzo - Tissue Antigens, 2003 - interscience.wiley.com Abstract: Type 1 diabetes (T1D) is an organ-specific autoimmune disease in which
the insulin-producing β cells in the pancreatic islets are selectively
eliminated. T cells specific for β-cell antigens are the mediators of this ... Cited by 60 - Related articles - BL Direct - All 5 versions
- ►jimmunol.org EL Masteller, MR Warner, W Ferlin, V … - The Journal of Immunology, 2003 - Am Assoc Immnol Type 1 diabetes is an autoimmune disorder caused by autoreactive T cells that
mediate destruction of insulin-producing cells of the pancreas. Studies have
shown that T cell tolerance can be restored by inducing a partial or ... Cited by 54 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org C Panagiotopoulos, H Qin, R Tan, CB … - Diabetes, 2003 - Am Diabetes Assoc Type 1 diabetes is an autoimmune disease in which pancreatic β-cells are
destroyed by cytotoxic T-cells that recognize peptide epitopes presented by HLA
class I molecules. The identification of human β-cell epitopes may ... Cited by 49 - Related articles - BL Direct - All 4 versions
- ►archives-ouvertes.fr [PDF] R Mallone, GT Nepom - Clinical Immunology, 2004 - Elsevier Selective expansion and activation of a very small number of antigen-specific
CD4 + T cells is a remarkable and essential property of the adaptive immune
response. Antigen-specific T cells were until recently identified only ... Cited by 44 - Related articles - All 7 versions
NC Schloot, G Meierhoff, M Karlsson Faresjö … - Journal of Autoimmunity, 2003 - Elsevier The identification of sensitive assay formats capable of distinguishing islet
autoreactive T cells directly ex vivo in blood is a major goal in type 1
diabetes research. Recently, much interest has been shown in the cytokine ... Cited by 43 - Related articles - All 4 versions
TP Di Lorenzo, M Peakman, BO Roep - Clinical and Experimental Immunology, 2007 - pubmedcentral.nih.gov T cell epitopes represent the molecular code words through which the adaptive
immune system communicates. In the context of a T cell-mediated autoimmune
disease such as type 1 diabetes, CD4 and CD8 T cell recognition of islet ... Cited by 43 - Related articles - BL Direct - All 5 versions
