- ►202.201.6.125 [PDF] B Kyewski, L Klein, 2006 - Annual Reviews Abstract Recent elucidation of the role of central tolerance in preventing
organ-specific autoimmunity has changed our concepts of self/nonself
discrimination. This paradigmatic shift is largely attributable to the ... Cited by 214 - Related articles - BL Direct - All 6 versions
- ►rupress.org J Derbinski, J Gabler, B Brors, S Tierling, S … - Journal of Experimental Medicine, 2005 - jem.rupress.org The role of central tolerance induction has recently been revised after the
discovery of promiscuous expression of tissue-restricted self-antigens in the
thymus. The extent of tissue representation afforded by this mechanism and ... Cited by 154 - Related articles - BL Direct - All 12 versions
A Liston, DHD Gray, S Lesage, AL Fletcher, … - Journal of Experimental Medicine, 2004 - jem.rupress.org Inactivation of the autoimmune regulator (Aire) gene causes a rare recessive
disorder, autoimmune polyendocrine syndrome 1 (APS1), but it is not known if
Aire-dependent tolerance mechanisms are susceptible to the quantitative ... Cited by 139 - Related articles - BL Direct - All 6 versions
- ►rupress.org J Gotter, B Brors, M Hergenhahn, B Kyewski - Journal of Experimental Medicine, 2004 - jem.rupress.org Promiscuous expression of tissue-specific self-antigens in the thymus imposes T
cell tolerance and protects from autoimmune diseases, as shown in animal
studies. Analysis of promiscuous gene expression in purified stromal cells ... Cited by 137 - Related articles - BL Direct - All 4 versions
- ►nih.gov K Thébault-Baumont, D Dubois-Laforgue, P … - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig Accumulating evidence favors a role for proinsulin as a key autoantigen in
diabetes. In the mouse, two proinsulin isoforms coexist. Most studies point to
proinsulin 2 as the major isoform recognized by T cells in the NOD mouse. ... Cited by 102 - Related articles - BL Direct - All 6 versions
- ►pnas.org H Kojima, M Fujimiya, K Matsumura, T … - Proceedings of the National Academy of Sciences, 2004 - National Acad Sciences Insulin-producing cells normally occur only in the pancreas and thymus.
Surprisingly, we found widespread insulin mRNA and protein expression in
different diabetic mouse and rat models, including streptozotocin-treated ... Cited by 92 - Related articles - BL Direct - All 17 versions
- ►nih.gov H Moriyama, N Abiru, J Paronen, K Sikora, E … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences It has been reported that an insulin 2 gene knockout, when bred onto nonobese
diabetic (NOD) mice, accelerates diabetes. We produced insulin 1 gene knockout
congenic NOD mice. In contrast to insulin 2, diabetes and insulitis were ... Cited by 79 - Related articles - BL Direct - All 10 versions
E Jaeckel, MA Lipes, H von Boehmer - Insulin (pmol/l) - microbio.uab.edu Although autoimmune diseases can be initiated by immunization with a single
antigen, it is not clear whether a single self antigen is essential for the
initiation and, perhaps, the perpetuation of spontaneous autoimmunity. Some ... Cited by 55 - Related articles - BL Direct - All 7 versions
- ►bmjjournals.com MA Kelly, ML Rayner, CH Mijovic, AH Barnett - Molecular Pathology, 2003 - Assoc Clin Pathol Type 1 diabetes is a T cell mediated autoimmune disease, characterised by the
selective destruction of pancreatic ß cells, and susceptibility is determined
by a combination of genetic and environmental factors. The environmental ... Cited by 53 - Related articles - BL Direct - All 8 versions
- ►nih.gov Q Tang, JY Adams, C Penaranda, K Melli, E … - Immunity, 2008 - Elsevier The dynamics of CD4 + effector T cells (Teff cells) and CD4 + Foxp3 + regulatory
T cells (Treg cells) during diabetes progression in nonobese diabetic mice was
investigated to determine whether an imbalance of Treg cells and Teff cells ... Cited by 53 - Related articles - All 7 versions
