H Kojima, M Fujimiya, K Matsumura, P … - Nature medicine, 2003 - nature.com To explore induced islet neogenesis in the liver as a strategy for the treatment
of diabetes, we used helper-dependent adenovirus (HDAD) to deliver the
pancreatic duodenal homeobox-1 gene (Ipf1; also known as Pdx-1) to ... Cited by 236 - Related articles - BL Direct - All 3 versions
M Zalzman, S Gupta, RK Giri, I Berkovich, BS … - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences Beta-cell replacement is considered to be the most promising approach for
treatment of type 1 diabetes. Its application on a large scale is hindered by a
shortage of cells for transplantation. Activation of insulin expression, ... Cited by 171 - Related articles - BL Direct - All 13 versions
A Liston, DHD Gray, S Lesage, AL Fletcher, … - Journal of Experimental Medicine, 2004 - jem.rupress.org Inactivation of the autoimmune regulator (Aire) gene causes a rare recessive
disorder, autoimmune polyendocrine syndrome 1 (APS1), but it is not known if
Aire-dependent tolerance mechanisms are susceptible to the quantitative ... Cited by 140 - Related articles - BL Direct - All 6 versions
- ►alphamedpress.org C Moriscot, F de Fraipont, MJ Richard, M … - Stem Cells, 2005 - AlphaMed Press Multipotential stem cells can be selected from the bone marrow by plastic
adhesion, expanded, and cultured. They are able to differentiate not only into
multiple cell types, including cartilage, bone, adipose and fibrous ... Cited by 114 - Related articles - All 7 versions
H Noguchi, H Kaneto, GC Weir, S Bonner- … - Diabetes, 2003 - Am Diabetes Assoc The pancreatic and duodenal homeobox factor-1 (PDX-1), also known as IDX-1/STF-1
/IPF1, a homeodomain-containing transcription factor, plays a central role in
regulating pancreatic development and insulin gene transcription. ... Cited by 109 - Related articles - BL Direct - All 6 versions
- ►pnas.org H Kojima, M Fujimiya, K Matsumura, T … - Proceedings of the National Academy of Sciences, 2004 - National Acad Sciences Insulin-producing cells normally occur only in the pancreas and thymus.
Surprisingly, we found widespread insulin mRNA and protein expression in
different diabetic mouse and rat models, including streptozotocin-treated ... Cited by 93 - Related articles - BL Direct - All 17 versions
- ►cell.com SK Chakrabarti, RG Mirmira - Trends in Endocrinology & Metabolism, 2003 - Elsevier Transcription factors orchestrate intricate pathways of cellular growth and
differentiation by regulating the rate of transcription of an array of genes.
Genetic and biochemical studies have begun to unravel the complex cascade ... Cited by 66 - Related articles - All 12 versions
- ►jbc.org SK Chakrabarti, J Francis, SM Ziesmann, JC … - Journal of Biological Chemistry, 2003 - ASBMB Histone modifying enzymes contribute to the activation or inactivation of
transcription by ultimately catalyzing the unfolding or further compaction,
respectively, of chromatin structure. Actively transcribed genes are ... Cited by 63 - Related articles - BL Direct - All 5 versions
Y Kajimoto, H Kaneto - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2004 - interscience.wiley.com Abstract: Oxidative stress is produced under diabetic conditions and is likely
involved in progression of pancreatic β-cell dysfunction found in diabetes.
Possibly caused by low levels of antioxidant enzyme expressions, pancreatic ... Cited by 58 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org H Kaneto, Y Nakatani, T Miyatsuka, T … - Diabetes, 2005 - Am Diabetes Assoc Diabetes is the most prevalent and serious metabolic disease, and the number of
diabetic patients worldwide is increasing. The reduction of insulin biosynthesis
in pancreatic β-cells is closely associated with the onset and progression ... Cited by 54 - Related articles - All 6 versions
