- ►shouxi.net S Del Guerra, R Lupi, L Marselli, M Masini, M … - Diabetes, 2005 - Am Diabetes Assoc To shed further light on the primary alterations of insulin secretion in type 2
diabetes and the possible mechanisms involved, we studied several functional and
molecular properties of islets isolated from the pancreata of 13 type 2 ... Cited by 107 - Related articles - All 5 versions
- ►endojournals.org P Marchetti, S Del Guerra, L Marselli, R Lupi, … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Several properties of pancreatic ß-cells in type 2 diabetes (T2D) were studied
by using islets isolated from T2D subjects. Moreover, because metformin has
protective effects on nondiabetic ß-cells exposed to high glucose or free ... Cited by 92 - Related articles - BL Direct - All 5 versions
G Sesti, M Cardellini, MA Marini, S Frontoni, … - Diabetes, 2003 - Am Diabetes Assoc It was reported that the common −866G/A polymorphism in the promoter of the
human uncoupling protein-2 (UCP2) gene, which enhances its trascriptional
activity, is associated with increased mRNA levels in human adipocytes and ... Cited by 87 - Related articles - BL Direct - All 4 versions
A Jellema, MPA Zeegers, EJM Feskens, PC … - Diabetologia, 2003 - Springer Aims/hypothesis. Several case-control studies have ex- amined the association
between the Gly972Arg variant in the IRS-1 gene and Type 2 diabetes, but most
had limited power and results could therefore be conflict- ing. Methods. We ... Cited by 75 - Related articles - BL Direct - All 5 versions
V Lyssenko, P Almgren, D Anevski, M Orho- … - PLoS Medicine, 2005 - medicine.plosjournals.org By using a Cox proportional hazard model, common variants in the PPARG (P12A),
CAPN10 (SNP43 and 44), KCNJ11 (E23K), UCP2 (−866G>A), and IRS1 (G972R) genes
were studied for their ability to predict T2D in 2,293 individuals ... Cited by 63 - Related articles - Cached - BL Direct - All 10 versions
- ►physiology.org K Otani, RN Kulkarni, AC Baldwin, J … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc Pancreatic -cell-restricted knockout of the insulin receptor results in
hyperglycemia due to impaired insulin secretion, suggesting that this cell is an
important target of insulin action. The present studies were undertaken in ... Cited by 60 - Related articles - BL Direct - All 3 versions
JC Florez, M Sjögren, N Burtt, M Orho- … - Diabetes, 2004 - Am Diabetes Assoc The insulin receptor substrate (IRS)-1 is an important component of the insulin
signal transduction cascade. Several reports suggest that a Gly→Arg change in
codon 972 is associated with type 2 diabetes and related traits, and a ... Cited by 49 - Related articles - BL Direct - All 4 versions
M Anello, R Lupi, D Spampinato, S Piro, M … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Little information is available on the insulin release
properties of pancreatic islets iso- lated from type 2 diabetic subjects. Since
mitochondria represent the site where important metabolites that regulate ... Cited by 42 - Related articles - All 3 versions
- ►diabetesjournals.org M Masini, D Campani, U Boggi, M Menicagli, N … - Diabetes Care, 2005 - Am Diabetes Assoc Many patients with chronic hepatitis C virus (HCV) develop type 2 diabetes (1).
This prevalence is much higher than that observed in the general population and
in patients with other chronic liver diseases such as hepatitis B virus, ... Cited by 34 - Related articles - All 5 versions
M Stumvoll - Diabetologia, 2004 - Springer Regulation of glycaemia represents a fundamental biological principle, and its
failure underlies Type 2 diabetes. The complex aetiology of Type 2 diabetes,
which probably involves a medley of molecular mech- anisms, requires ... Cited by 33 - Related articles - BL Direct - All 6 versions
