- ►endojournals.org H Bays, L Mandarino, RA DeFronzo - Journal of Clinical Endocrinology & …, 2004 - Endocrine Soc Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance in liver and muscle and
impaired insulin secretion. Considerable evidence also implicates deranged adipocyte metabolism
and altered fat topography in the pathogenesis of glucose intolerance in T2DM. 1) Fat ... Cited by 245 - Related articles - All 4 versions
RP Robertson, J Harmon, POT Tran, V Poitout - Diabetes, 2004 - Am Diabetes Assoc The relentless decline in β-cell function frequently observed in type 2 diabetic patients, despite
optimal drug management, has variously been attributed to glucose toxicity and lipotoxicity. The
former theory posits hyperglycemia, an outcome of the disease, as a secondary force that ... Cited by 202 - Related articles - BL Direct - All 5 versions
- ►sallyosborne.com [PDF] JE Schaffer - Current opinion in lipidology, 2003 - journals.lww.com Recent findings: Excess lipid accumulation in non-adipose tissues may arise in the setting of
high plasma free fatty acids or triglycerides. Alternatively, lipid overload results from mismatch
between free fatty acid import and utilization. Evidence from human studies and animal ... Cited by 197 - Related articles - BL Direct - All 8 versions
- ►nih.gov M Prentki, CJ Nolan - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The major focus of this Review is on the mechanisms of islet β cell failure in the pathogenesis
of obesity-associated type 2 diabetes (T2D). As this demise occurs within the context of β cell
compensation for insulin resistance, consideration is also given to the mechanisms ... Cited by 199 - Related articles - BL Direct - All 7 versions
W El-Assaad, J Buteau, ML Peyot, C Nolan, R Roduit, S … - Endocrinology, 2003 - Endocrine Soc We have proposed the "glucolipotoxicity" hypothesis in which elevated free fatty acids (FFAs)
together with hyperglycemia are synergistic in causing islet ß-cell damage because high glucose
inhibits fat oxidation and consequently lipid detoxification. The effects of 1–2 d culture of ... Cited by 174 - Related articles - BL Direct - All 5 versions
AE Butler, J Janson, WC Soeller, PC Butler - Diabetes, 2003 - Am Diabetes Assoc Nondiabetic obese humans adapt to insulin resistance by increasing β-cell mass. In
contrast, obese humans with type 2 diabetes have an ∼60% deficit in β-cell mass. Recent studies
in rodents reveal that β-cell mass is regulated, increasing in response to insulin ... Cited by 146 - Related articles - BL Direct - All 6 versions
- ►endojournals.org I Kharroubi, L Ladriere, AK Cardozo, Z Dogusan, M … - Endocrinology, 2004 - Endocrine Soc Apoptosis is probably the main form of ß-cell death in both type 1 diabetes mellitus (T1DM) and
T2DM. In T1DM, cytokines contribute to ß-cell destruction through nuclear factor- B (NF- B)
activation. Previous studies suggested that in T2DM high glucose and free fatty acids ... Cited by 136 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org J Mu, J Woods, YP Zhou, RS Roy, Z Li, E Zycband, Y … - Diabetes, 2006 - Am Diabetes Assoc Inhibitors of dipeptidyl peptidase-4 (DPP-4), a key regulator of the actions of incretin
hormones, exert antihyperglycemic effects in type 2 diabetic patients. A major unanswered question
concerns the potential ability of DPP-4 inhibition to have beneficial disease-modifying ... Cited by 127 - Related articles - BL Direct - All 9 versions
H Kolb, T Mandrup-Poulsen - Diabetologia, 2005 - Springer Abstract Subclinical, low-grade systemic inflammation has been observed in patients with type
2 diabetes and in those at increased risk of the disease. This may be more than an
epiphenomenon. Alleles of genes encoding immune/ inflammatory mediators are ... Cited by 118 - Related articles - BL Direct - All 5 versions
- ►nursing2008.com L Hutley, JB Prins - The American journal of the medical sciences, 2005 - journals.lww.com ABSTRACT: Obesity and the metabolic syndrome have both reached pandemic proportions.
Together they have the potential to impact on the incidence and severity of cardiovascular
pathologies, with grave implications for worldwide health care systems. The metabolic ... Cited by 116 - Related articles - All 6 versions
