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Scholar Results 1 - 10 of about 106 citing Sudre: Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the.... (0.11 sec) 

Enhancing incretin action for the treatment of type 2 diabetes

- diabetesjournals.org
DJ Drucker - Diabetes Care, 2003 - Am Diabetes Assoc
RESULTS—Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic
peptide (GIP) exert important effects on β-cells to stimulate glucose-dependent
insulin secretion. Both peptides also regulate β-cell proliferation and ...
Cited by 283 - Related articles - All 13 versions

Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions …


AM Lambeir, C Durinx, S Scharpé, I De … - Critical reviews in clinical laboratory sciences, 2003 - informahealthcare.com
Laboratory of Medical Biochemistry, University of Antwerp, Universiteitsplein 1,
Wilrijk, Belgium ... Referee: Dr. Albert Adam, Faculté de Pharmace,
Université de Montréal, 2900 Blvd. Edouard—Montpetit, CP succursale ...
Cited by 166 - Related articles - BL Direct - All 9 versions

Dipeptidyl peptidase IV inhibitor treatment stimulates β-cell survival and islet neogenesis in …

- diabetesjournals.org
JA Pospisilik, J Martin, T Doty, JA Ehses, N … - Diabetes, 2003 - Am Diabetes Assoc
Recent studies into the physiology of the incretins glucose-dependent
insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) have added
stimulation of β-cell growth, differentiation, and cell survival to well- ...
Cited by 161 - Related articles - BL Direct - All 4 versions

Therapeutic strategies based on glucagon-like peptide 1

- diabetesjournals.org
CF Deacon - Diabetes, 2004 - Am Diabetes Assoc
Glucagon-like peptide (GLP)-1 is an incretin hormone with potent
glucose-dependent insulinotropic and glucagonostatic actions, trophic effects on
the pancreatic β-cells, and inhibitory effects on gastrointestinal ...
Cited by 154 - Related articles - BL Direct - All 5 versions

Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic β …

- diabetesjournals.org
J Mu, J Woods, YP Zhou, RS Roy, Z Li, E … - Diabetes, 2006 - Am Diabetes Assoc
Inhibitors of dipeptidyl peptidase-4 (DPP-4), a key regulator of the actions of
incretin hormones, exert antihyperglycemic effects in type 2 diabetic patients.
A major unanswered question concerns the potential ability of DPP-4 ...
Cited by 126 - Related articles - BL Direct - All 9 versions

Therapeutic potential of dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes


DJ Drucker - eid, 2003 - informahealthcare.com
Incretins are peptide hormones, exemplified by glucose-dependent insulino-
tropic peptide and glucagon-like peptide 1 that are released from the gut in
response to nutrient ingestion and enhance glucose-stimulated insulin ...
Cited by 118 - Related articles - All 6 versions

Inhibitors of dipeptidyl peptidase IV: a novel approach for the prevention and treatment of …


CF Deacon, B Ahrén, JJ Holst - eid, 2004 - informahealthcare.com
Inhibitors of the enzyme dipeptidyl peptidase IV (DPP IV) are of increasing
interest to both diabetologists and the pharmaceutical industry alike, as they
may become established as the next member of the oral antidiabetic class of ...
Cited by 102 - Related articles - All 7 versions

Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral …

- diabetesjournals.org
JA Pospisilik, SG Stafford, HU Demuth, CHS … - Diabetes, 2002 - Am Diabetes Assoc
Upon release into circulation, the potent insulin secretagogues
glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1
(GLP-1) are rapidly cleaved and inactivated by the enzyme dipeptidyl ...
Cited by 99 - Related articles - BL Direct - All 6 versions

Prolyl peptidases: a serine protease subfamily with high potential for drug discovery

- activx.com [PDF] 
JS Rosenblum, JW Kozarich - Current opinion in chemical biology, 2003 - Elsevier
Much attention has recently been given to a class of proteases that cleave
proteins and peptides after proline residues. This class includes dipeptidyl
peptidase IV (DPP IV; also termed CD26), fibroblast activation protein α ...
Cited by 94 - Related articles - All 5 versions

The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion

- bcell.org [PDF] 
PE MacDonald, W El-kholy, MJ Riedel, AMF … - Diabetes, 2002 - Am Diabetes Assoc
The physiological effects of glucagon-like peptide-1 (GLP-1) are of immense
interest because of the potential clinical relevance of this peptide. Produced
in intestinal L-cells through posttranslational processing of the ...
Cited by 95 - Related articles - BL Direct - All 4 versions


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