- ►aspetjournals.org L Virag, C Szabo - Pharmacological Reviews, 2002 - ASPET Poly(ADP-ribose) polymerase-1 (PARP-1) is a member of the PARP enzyme family consisting of PARP-1
and several recently identified novel poly(ADP-ribosylating) enzymes. PARP-1 is an abundant nuclear
protein functioning as a DNA ... Cited by 603 - Related articles - BL Direct - All 7 versions
WL Suarez-Pinzon, JG Mabley, R Power, C Szabó, A … - Diabetes, 2003 - Am Diabetes Assoc Poly (ADP-ribose) polymerase (PARP) is a nuclear enzyme that consumes NAD in response to DNA strand
breaks. The PARP inhibitor nicotinamide prevents NAD consumption and protects islet β-cells from
chemically induced necrosis but not ... Cited by 28 - Related articles - BL Direct - All 9 versions
CA de la Lastra, I Villegas, S Sanchez- … - Current pharmaceutical …, 2007 - ingentaconnect.com Abstract: Poly(ADP-ribose) polymerase (PARP) comprise of a family of enzymes which catalyses
poly(ADP- ribosyl)ation of DNA-binding proteins. To date, seven isoforms have been identified:
PARP-1, PARP-2, PARP-3, PARP- 4 ... Cited by 25 - Related articles - BL Direct - All 3 versions
C Szabó - Pharmacological research, 2005 - Elsevier Activation of poly(ADP-ribose) polymerase (PARP) plays a role in the pathogenesis of β-cell
necrosis that occurs in response to autoimmune disease associated with Type I diabetes. In addition,
PARP activation also plays a role ... Cited by 27 - Related articles - All 4 versions
N Babaya, H Ikegami, T Fujisawa, K Nojima, M Itoi- … - … and Biophysical Research …, 2005 - Elsevier To study the contribution of β-cell vulnerability to susceptibility to diabetes, we studied β-cell
vulnerability to a single high dose of streptozotocin (STZ) in an animal model of type 2 diabetes,
the NSY mouse, a sister strain of ... Cited by 10 - Related articles - All 4 versions
- ►adisonline.com [PDF] N Petrovsky, D Silva, DA Schatz - Drugs, 2002 - ingentaconnect.com Abstract Type 1 (insulin-dependent) diabetes mellitus results from selective immune- mediated
destruction of pancreatic islet β cells. Strategies to prevent or reverse the development of
diabetes can be divided into three ... Cited by 10 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] JA Yalowitz, S Xiao, MP Biju, AC Antony, OW … - Biochemical …, 2004 - pubmedcentral.nih.gov NMNAT (nicotinamide 5 -mononucleotide adenylyltransferase; EC 2.7.7.1) catalyses the transfer of the
adenylyl group from ATP to NMN to form NAD. We have cloned a novel human NMNAT cDNA, designated
hNMNAT-2, from human brain. The ... Cited by 8 - Related articles - BL Direct - All 8 versions
J Yelamos, FJ Oliver - Inmunologia, 2002 - revista.inmunologia.org RESUMEN La respuesta inflamatoria se caracteriza por una exp resión exacerbada de genes
pro-inflamatorios en re s- puesta a diferentes estímulos. El estudio de los mecanis- mos
moleculares involucrados en las ... Cited by 8 - Related articles - View as HTML - All 3 versions
- ►daegu.ac.kr [PDF] C Aspord, S Rome, C Thivolet - Journal of autoimmunity, 2004 - Elsevier The specific contributions of islet cell microenvironment during the development of autoimmune type
1 diabetes remain unclear. The aims of this study were to identify early immune-driven abnormalities
in islets and pancreatic lymph ... Cited by 7 - Related articles - All 5 versions
- ►physiology.org APW Johnston, JE Campbell, JG Found, … - American Journal of …, 2007 - Am Physiological Soc Streptozotocin (STZ) is used extensively to induce pancreatic -cell death and ultimately diabetes
mellitus in animal models. However, the direct effects of STZ on muscle are largely unknown. To
delineate the effects of STZ from ... Cited by 3 - Related articles - BL Direct - All 5 versions
