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Scholar Results 1 - 10 of about 77 citing Hegarty: Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal.... (0.13 sec) 

The role of intramuscular lipid in insulin resistance


BD Hegarty, SM Furler, J Ye, GJ Cooney, EW … - Acta Physiologica Scandinavica, 2003 - interscience.wiley.com
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Cited by 120 - Related articles - BL Direct - All 4 versions

PPARalpha/gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed …

- physiology.org
JM Ye, MA Iglesias, DG Watson, B Ellis, L … - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc
Peroxisome proliferator-activated receptor (PPAR) and PPAR agonists lower lipid
accumulation in muscle and liver by different mechanisms. We investigated
whether benefits could be achieved on insulin sensitivity and lipid ...
Cited by 86 - Related articles - BL Direct - All 3 versions

Glucose intolerance and resistin expression in rat offspring exposed to ethanol in utero: …

- endojournals.org
L Chen, BLG Nyomba - Endocrinology, 2003 - Endocrine Soc
High-fat-fed offspring had increased adiposity, serum leptin, and muscle
uncoupling protein-3, but decreased adiponectin mRNA, compared with
corresponding chow-fed groups. ETOH-exposed offspring had normal ...
Cited by 59 - Related articles - BL Direct - All 9 versions

Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle


N Turner, CR Bruce, SM Beale, KL Hoehn, T … - Diabetes, 2007 - Am Diabetes Assoc
A reduced capacity for mitochondrial fatty acid oxidation in skeletal muscle has
been proposed as a major factor leading to the accumulation of intramuscular
lipids and their subsequent deleterious effects on insulin action. Here, we ...
Cited by 60 - Related articles - BL Direct - All 5 versions

Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced …


C Bonnard, A Durand, S Peyrol, E Chanseaume … - The Journal of Clinical Investigation, 2008 - pubmedcentral.nih.gov
Mitochondrial dysfunction in skeletal muscle has been implicated in the
development of type 2 diabetes. However, whether these changes are a cause or a
consequence of insulin resistance is not clear. We investigated the ...
Cited by 51 - Related articles - BL Direct - All 8 versions

Peroxisome Proliferator-Activated Receptor (PPAR) Activation Induces Tissue-Specific …

- endojournals.org
BD Hegarty, SM Furler, ND Oakes, EW … - Endocrinology, 2004 - Endocrine Soc
Agonists of peroxisome proliferator-activated receptors (PPARs) have emerged as
important pharmacological agents for improving insulin action. A major mechanism
of action of PPAR agonists is thought to involve the alteration of the ...
Cited by 45 - Related articles - BL Direct - All 4 versions

Real-time assessment of postprandial fat storage in liver and skeletal muscle in health and …

- physiology.org
B Ravikumar, PE Carey, JEM Snaar, DK … - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc
Liver and skeletal muscle triglyceride stores are elevated in type 2 diabetes
and correlate with insulin resistance. As postprandial handling of dietary fat
may be a critical determinant of tissue triglyceride levels, we quantified ...
Cited by 41 - Related articles - All 4 versions

Nicotinic acid-induced insulin resistance is related to increased circulating fatty acids and …


AM Poynten, S Khee Gan, AD Kriketos, AO' … - Metabolism, 2003 - Elsevier
Insulin resistance is associated with increased circulating lipids and skeletal
muscle lipid content. Chronic nicotinic acid (NA) treatment reduces insulin
sensitivity and provides a model of insulin resistance. We hypothesized ...
Cited by 41 - Related articles - All 10 versions

CD36 in myocytes channels fatty acids to a lipase-accessible triglyceride pool that is related …


CC Bastie, T Hajri, VA Drover, PA Grimaldi, … - Diabetes, 2004 - Am Diabetes Assoc
High levels of intramyocellular triglycerides are linked to insulin resistance
and reflect conditions in which fatty acid uptake exceeds the myocyte oxidative
capacity. CD36 facilitates fatty acid uptake by myocytes, and its level is ...
Cited by 39 - Related articles - BL Direct - All 4 versions

Potential mechanisms and consequences of cardiac triacylglycerol accumulation in insulin- …

- physiology.org
LL Atkinson, R Kozak, SE Kelly, A Onay- … - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc
The accumulation of intracellular triacylglycerol (TG) is highly correlated with
muscle insulin resistance. However, it is controversial whether the accumulation
of TG is the result of increased fatty acid supply, decreased fatty acid ...
Cited by 38 - Related articles - BL Direct - All 4 versions


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