- ►cell.com P Arner - Trends in Endocrinology & Metabolism, 2003 - Elsevier Globally, the prevalence of obesity is escalating, and insulin resistance resulting from increased
(predominantly visceral) adipose tissue mass has been identified as a key factor that could drive
parallel rises in type 2 diabetes mellitus (T2DM) prevalence. Correlations between these ... Cited by 234 - Related articles - All 11 versions
- ►endojournals.org H Motoshima, X Wu, MK Sinha, VE Hardy, EL … - Journal of Clinical …, 2002 - Endocrine Soc Adiponectin is an adipocyte-derived plasma protein with insulin-sensitizing and antiatherosclerotic
properties. Because adipose tissue depots differ in the strength of their association with the adverse
metabolic consequences of obesity, we studied the secretion of adiponectin in vitro from ... Cited by 218 - Related articles - BL Direct - All 4 versions
- ►nih.gov AW Norris, L Chen, SJ Fisher, I Szanto, M … - Journal of Clinical …, 2003 - Am Soc Clin Investig Activation of peroxisome proliferator-activated receptor γ (PPARγ) by thiazolidinediones
(TZDs) improves insulin resistance by increasing insulin-stimulated glucose disposal in skeletal
muscle. It remains debatable whether the effect of TZDs on muscle is direct or indirect via ... Cited by 209 - Related articles - BL Direct - All 6 versions
C Lagathu, JP Bastard, M Auclair, M Maachi, J … - … and Biophysical Research …, 2003 - Elsevier IL-6 has emerged as an important cytokine upregulated in states of insulin resistance such as
type 2 diabetes. We evaluated the chronic effect of IL-6 on insulin signaling in 3T3-F442A and
3T3-L1 adipocytes. First, cells responded to a chronic treatment with IL-6 by initiating an ... Cited by 141 - Related articles - All 5 versions
KA Virtanen, K Hällsten, R Parkkola, T Janatuinen, F … - Diabetes, 2003 - Am Diabetes Assoc We evaluated the effects of rosiglitazone (4 mg bid) and metformin (1 g bid) monotherapy for
26 weeks on adipose tissue insulin-stimulated glucose uptake in patients (n = 41) with type 2
diabetes. Before and after the treatment, glucose uptake was measured using 2-[ 18 ... Cited by 112 - Related articles - BL Direct - All 4 versions
GD Tan, BA Fielding, JM Currie, SM Humphreys, M … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: We investigated the effects of rosiglitazone on NEFA and triglyceride
metabolism in type 2 diabetes. Methods: In a double-blind, placebo-con- trolled, cross-over study
of rosiglitazone in diet-treated type 2 diabetic subjects, we measured arteriovenous dif- ... Cited by 85 - Related articles - All 2 versions
- ►rupress.org T Matsuki, R Horai, K Sudo, Y Iwakura - Journal of Experimental …, 2003 - jem.rupress.org IL-1 is a proinflammatory cytokine that plays important roles in inflammation. However, the role
of this cytokine under physiological conditions is not known completely. In this paper, we analyzed
the role of IL-1 in maintaining body weight because IL-1 receptor antagonist–deficient (IL- ... Cited by 81 - Related articles - BL Direct - All 6 versions
JN Fain, SW Bahouth, AK Madan - International Journal of Obesity, 2004 - nature.com RESULTS: We found that the maximal release of TNF was seen during the first 4 h of a 48-h
incubation by explants of human adipose tissue in primary culture. Over 95% of the TNF released
to the medium by human adipose tissue explants over a 4-h incubation came from the ... Cited by 72 - Related articles - BL Direct - All 4 versions
M Shimamura, M Matsuda, S Kobayashi, Y Ando, M … - … and Biophysical Research …, 2003 - Elsevier Our previous work identified a genetic mutation in the gene encoding angiopoietin-like protein
3 (Angptl3) in KK/Snk mice (previously KK/San), a mutant strain of KK obese mice. KK/Snk had
significantly lower plasma triglyceride and free fatty acid (FFA) than KK mice. Human ... Cited by 54 - Related articles - BL Direct - All 4 versions
- ►physiology.org J Sutinen, K Kannisto, E Korsheninnikova, … - American Journal of …, 2004 - Am Physiological Soc Highly active antiretroviral therapy (HAART) has improved the prognosis of human immunodeficiency
virus (HIV)-infected patients but is associated with severe adverse events, such as lipodystrophy
and insulin resistance. Rosiglitazone did not increase subcutaneous fat in patients with ... Cited by 46 - Related articles - BL Direct - All 7 versions
