- ►nih.gov I Reynisdottir, G Thorleifsson, R Benediktsson, G … - The American Journal of …, 2003 - Elsevier We report a genomewide linkage study of type 2 diabetes (T2D [MIM 125853]) in the Icelandic
population. A list of type 2 diabetics was cross-matched with a computerized genealogical database
clustering 763 type 2 diabetics into 227 families. The diabetic patients and their relatives ... Cited by 97 - Related articles - BL Direct - All 14 versions
V Schulla, E Renström, R Feil, S Feil, I Franklin … - The EMBO …, 2003 - pubmedcentral.nih.gov Insulin is secreted from pancreatic β cells in response to an elevation of cytoplasmic Ca 2+ resulting
from enhanced Ca 2+ influx through voltage-gated Ca 2+ channels. Mouse β cells express several
types of Ca 2+ channel (L-, R- and possibly P/Q-type). β cell-selective ablation of the ... Cited by 75 - Related articles - All 3 versions
- ►chestpubs.org WOC Cookson - CHEST-CHICAGO-, 2002 - Springer Asthma is the most common chronic disease of childhood, affecting an estimated 155 million
individuals in the world. The cost of treating the dis- ease in the United States is approx $6 billion
dollars per annum (1). More than half of this expense is spent on hospital care and 80% is ... Cited by 75 - Related articles - BL Direct - All 13 versions
- ►diabetesjournals.org MCY Ng, WY So, NJ Cox, VKL Lam, CS Cockram, … - Diabetes, 2004 - Am Diabetes Assoc We conducted an autosomal genome scan to map loci for type 2 diabetes in a Hong Kong Chinese
population. We studied 64 families, segregating type 2 diabetes, of which 57 had at least one
member with an age at diagnosis of ≤40 years. These families included a total of 126 ... Cited by 48 - Related articles - BL Direct - All 6 versions
TM Frayling, CM Lindgren, JC Chevre, S Menzel, M … - Diabetes, 2003 - Am Diabetes Assoc Maturity-onset diabetes of the young (MODY) is a heterogeneous single gene disorder characterized
by non–insulin-dependent diabetes, an early onset and autosomal dominant inheritance. Mutations
in six genes have been shown to cause MODY. Approximately 15–20% of families fitting ... Cited by 41 - Related articles - BL Direct - All 6 versions
S Ellard, K Colclough - Human mutation, 2006 - interscience.wiley.com Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes mellitus characterized
by autosomal dominant inheritance, early age of onset (often <25 years of age), and pancreatic
-cell dysfunction. MODY is both clinically and genetically heterogeneous, with six different ... Cited by 33 - Related articles - BL Direct - All 4 versions
TM Frayling, S Wiltshire, GA Hitman, M Walker, JC Levy … - Diabetes, 2003 - Am Diabetes Assoc A young onset of type 2 diabetes is likely to result, in part, from greater genetic susceptibility.
Young-onset families may therefore represent a group in which genes are more easily detectable
by linkage. To test this hypothesis, we conducted age at diagnosis (AAD) stratified linkage ... Cited by 29 - Related articles - BL Direct - All 5 versions
KR Owen, A Stride, S Ellard, AT Hattersley - Diabetes Care, 2003 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—A total of 268 unselected UK Caucasian subjects diagnosed
at ages 18–45 years and not treated with permanent insulin for ≤6 months were studied. All
subjects underwent clinical assessment and screening for GAD antibodies (GADA) and ... Cited by 30 - Related articles - BL Direct - All 6 versions
SMS Mitchell, TM Frayling - Molecular Genetics and Metabolism, 2002 - Elsevier The study of maturity-onset diabetes of the young (MODY), an autosomal dominant form of
early-onset diabetes mellitus characterised by defective insulin secretion has been extremely
successful in two ways. Firstly it has enabled definitive diagnosis for patients. This allows ... Cited by 26 - Related articles - BL Direct - All 3 versions
- ►endojournals.org SM Clee, AD Attie - Endocrine reviews, 2007 - Endocrine Soc Inbred mouse strains provide genetic diversity comparable to that of the human population. Like
humans, mice have a wide range of diabetes-related phenotypes. The inbred mouse strains
differ in the response of their critical physiological functions, such as insulin sensitivity, ... Cited by 29 - Related articles - BL Direct - All 4 versions
